Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation

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• 作者：Toshihiro Furuta (1) (2)
  Masayuki Yamaguchi (1)
  Ryutaro Nakagami (1) (3)
  Masaaki Akahane (4)
  Manabu Minami (5)
  Kuni Ohtomo (4)
  Hirofumi Fujii (1)
  
• 关键词：Magnetic resonance imaging ; Kupffer cells ; Radiation ; Rats ; SPIO
• 刊名：Magnetic Resonance Materials in Physics, Biology and Medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：27
• 期：6
• 页码：501-508
• 全文大小：1,139 KB
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  2. Masui T, Yan H, Kosugi I, Sakamoto S, Nishimura T, Takahashi M, Kaneko M, Fritz-Zieroth B (1996) Assessment of early radiation effects on the liver. Comparison of SPECT and MR. Acta Radiol 37(5):665-71 CrossRef
  3. Morimoto N, Ebara M, Kato H, Obata T, Fujita J, Kondo F, Tsujii H, Saisho H (1999) Early detection of radiation-induced liver injury in rat by superparamagnetic iron oxide-enhanced MR imaging. J Magn Reson Imaging 9(4):573-78 CrossRef
  4. Yoshioka H, Itai Y, Saida Y, Mori K, Mori H, Okumura T (2000) Superparamagnetic iron oxide-enhanced MR imaging for early and late radiation-induced hepatic injuries. Magn Reson Imaging 18(9):1079-088 CrossRef
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  8. Furuta T, Yamaguchi M, Nakagami R, Akahane M, Minami M, Ohtomo K, Moriyama N, Fujii H (2013) Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images: an experimental study in rat livers with gadolinium chloride-induced Kupffer cell damage. Magn Reson Mater Phy 26(3):313-24 CrossRef
  9. Mitsuda M, Yamaguchi M, Nakagami R, Furuta T, Sekine N, Niitsu M, Moriyama N, Fujii H (2013) Intensity correction method customized for multi-animal abdominal MR imaging with 3T clinical scanner and multi-array coil. Magn Reson Med Sci 12(2):95-03 CrossRef
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• 作者单位：Toshihiro Furuta (1) (2)
  Masayuki Yamaguchi (1)
  Ryutaro Nakagami (1) (3)
  Masaaki Akahane (4)
  Manabu Minami (5)
  Kuni Ohtomo (4)
  Hirofumi Fujii (1)
  
  1. Division of Functional Imaging, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan
  2. Department of Radiology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  3. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
  4. Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  5. Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
  
• ISSN：1352-8661

文摘

Object To determine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging could demonstrate signal recovery delay in irradiated areas of rat livers. We also investigated the relationship between MR imaging and histological findings. Materials and methods Twelve rats received 20?μmol iron/kg of SPIO followed by X-irradiation to the right upper abdomen 4?h later. Radiation doses were 0, 50 and 70?Gy. Hepatic signals were assessed on unenhanced T 2 * -weighted images for up to 7?days using a 9.4-Tesla scanner. The livers were excised on day 7 and examined histologically. Results Normalized relative signal intensity of 70?Gy-irradiated right liver lobe (2.36?±?0.22) and 50?Gy-irradiated right liver lobe (2.37?±?0.46) was significantly lower than that of the non-irradiated right liver lobe (4.04?±?0.28) on day 7, respectively (p?p? Conclusion Superparamagnetic iron oxide-enhanced MR imaging could demonstrate signal recovery delay in irradiated areas of rat livers. It seems that the signal recovery delay in irradiated areas was due to SPIO-derived iron deposition. Hepatic signal recovery could be a novel diagnostic marker for delineation of irradiated areas.