Bilateral pre- and postcentral gyrus volume positively correlates with T2-SNR of putamen in healthy adults
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- 作者：Masami Goto (1)
Osamu Abe (2)
Shigeki Aoki (3)
Tosiaki Miyati (4)
Hidemasa Takao (5)
Naoto Hayashi (6)
Harushi Mori (5)
Akira Kunimatsu (5)
Kenji Ino (1)
Keiichi Yano (1)
Kuni Ohtomo (5) - 关键词：Aging ; Gray matter volume ; Iron ; Magnetic resonance imaging ; Voxel ; based morphometry
- 刊名：Neuroradiology
- 出版年：2013
- 出版时间：February 2013
- 年：2013
- 卷：55
- 期：2
- 页码：245-250
- 全文大小：204KB
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Osamu Abe (2)
Shigeki Aoki (3)
Tosiaki Miyati (4)
Hidemasa Takao (5)
Naoto Hayashi (6)
Harushi Mori (5)
Akira Kunimatsu (5)
Kenji Ino (1)
Keiichi Yano (1)
Kuni Ohtomo (5)
1. Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
2. Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
3. Department of Radiology, Juntendo University, Bunkyo, Japan
4. Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
5. Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
6. Department of Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo Hospital, Tokyo, Japan - ISSN：1432-1920
文摘
Introduction The aim of the present study was to investigate the correlation between local gray matter volume and signal-to-noise ratio on T2-weighted imaging (T2-SNR) of putamen in healthy adults using two tools: voxel-based morphometry (VBM) treating age as a confounding covariate to control for age-related gray matter volume changes and high spatial resolution T1-weighted imaging acquired with a 3.0-T magnetic resonance (3T-MR) scanner. Methods Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1,380 healthy participants. T2-SNR of putamen was defined as A/B, where A is the mean T2-weighted signal intensity (T2-SI) in the right and left sides of putamen, and B is the background noise. The software Statistical Parametric Mapping 5 was used for image segmentation. The association between T2-SNR of putamen and gray matter volume was assessed with VBM, treating age as a confounding covariate. Results A significant positive correlation was obtained between T2-SNR of putamen and bilateral pre- and postcentral gyrus volume. Conclusion To the best of our knowledge, this is the first VBM study to show an age-independent relationship between T2-SNR of putamen and bilateral pre- and postcentral gyrus volumes in healthy adults.