Human milk composition differs in healthy mothers and mothers with celiac disease
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- 作者：Marta Olivares ; Simone Albrecht ; Giada De Palma…
- 关键词：Celiac disease ; Human milk ; Immunity ; Microbiota
- 刊名：European Journal of Nutrition
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：54
- 期：1
- 页码：119-128
- 全文大小：420 KB
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文摘
Purpose To investigate whether breast-milk composition and microbiota differ in healthy mothers and mothers with celiac disease (CD) to ultimately contribute to identify additional factors determining CD risk. Methods Breast-milk samples from healthy mothers (n?=?12) and mothers with CD (n?=?12) were collected. Cytokines and secretory immunoglobulin A (sIgA) were analyzed by bead-arrays and flow cytometry and human milk oligosaccharides (HMOs) were assessed by capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection. Breast-milk microbiota composition was analyzed by conventional and quantitative real-time PCR. Result Breast milk from CD mothers showed significantly lower levels of interleukin (IL) 12p70 (P?P?P?P?N-tetraose content (P?Bifidobacterium spp. (P?B. fragilis group (P? Conclusion CD mothers-breast milk is characterized by a reduced abundance of immunoprotective compounds (TGF-β1 and sIgA) and bifidobacteria. The reduction in these components could theoretically diminish the protective effects of breast-feeding on the child’s future risk of developing CD.