RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures
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- 作者：Francianne Gomes Andrade (5)
Juliana Montibeller Furtado-Silva (5) (6)
Bruno Alves de Aguiar Gon?alves (5)
Luiz Claudio Santos Thuler (5)
Thayana Concei??o Barbosa (5)
Mariana Emerenciano (5)
André Siqueira (6)
Maria S Pombo-de-Oliveira (5) - 关键词：RAS mutation ; NQO1 ; MLL ; Tobacco smoking exposures ; Childhood leukaemia
- 刊名：BMC Cancer
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：14
- 期：1
- 全文大小：243 KB
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45. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/14/133/prepub - 作者单位：Francianne Gomes Andrade (5)
Juliana Montibeller Furtado-Silva (5) (6)
Bruno Alves de Aguiar Gon?alves (5)
Luiz Claudio Santos Thuler (5)
Thayana Concei??o Barbosa (5)
Mariana Emerenciano (5)
André Siqueira (6)
Maria S Pombo-de-Oliveira (5)
5. Clinical Research Program, Research Centre, Instituto Nacional de Cancer, INCA, Rio de Janeiro, Brazil
6. Universidade do Estado do Amazonas, Manaus, AM, Brazil - ISSN：1471-2407
文摘
Background Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RAS mut) in acute myeloid leukaemia (AML), which has been associated with intra-uterine chemical exposures. A case-case study was conducted in order to explore maternal and child exposures to tobacco smoking associations with early age leukaemia (EAL). Methods Covariables of reference were MLL rearrangements (MLL-r), RAS mut and NQO1 rs1800566 (C609T). Samples from 150 acute lymphoblastic leukaemia (ALL) and 85 AML were included. Maternal exposures were assessed using a structured questionnaire with demographic, personal habits and residence history information. Restriction fragment length polymorphism and denaturing high performance liquid chromatography were used to screen FLT3, KRAS, and NRAS mutations; direct sequencing was performed to validate the results. NQO1 polymorphism was detected by real-time allelic discrimination technique. Results Overall, RAS mut were detected in 28.7% of EAL cases; BRAF mut was found only in one AML patient. Higher rate of KRAS mut was found in ALL (30.3%) compared to AML (20.8%) with MLL-r; RAS mut showed an association with second-hand tobacco smoking exposures (OR, 3.06, 95% CI, 1.03-9.07). A considerable increased risk for EAL with the combination of RAS mut and NQO1 609CT (OR, 4.24, 95% CI, 1.24-14.50) was observed. Conclusions Our data demonstrated the increased risk association between maternal smoking and EAL with MLL-r. Additionally, suggests that children second-hand tobacco exposures are associated with increased risk of EAL with RAS mut modulated by NQO1 rs1800566 (C609T).