Association of Serum Levels of Iron, Copper, and Zinc, and Inflammatory Markers with Bacteriological Sputum Conversion During Tuberculosis Treatment
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- 作者：Milena Lima de Moraes (1) (2)
Daniela Maria de Paula Ramalho (2)
Karina Neves Delogo (2)
Pryscila Fernandes Campino Miranda (2)
Eliene Denites Duarte Mesquita (3)
Hedi Marinho de Melo Guedes de Oliveira (4)
Ant?nio Ruffino Netto (5)
Marcelino José dos Anjos (6)
Afranio Lineu Kritski (2)
Martha Maria de Oliveira (2) - 关键词：Iron ; Copper ; Zinc ; Tuberculosis ; Smear
- 刊名：Biological Trace Element Research
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：160
- 期：2
- 页码：176-184
- 全文大小：605 KB
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Daniela Maria de Paula Ramalho (2)
Karina Neves Delogo (2)
Pryscila Fernandes Campino Miranda (2)
Eliene Denites Duarte Mesquita (3)
Hedi Marinho de Melo Guedes de Oliveira (4)
Ant?nio Ruffino Netto (5)
Marcelino José dos Anjos (6)
Afranio Lineu Kritski (2)
Martha Maria de Oliveira (2)
1. Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
2. Tuberculosis Research Centre, Academic Tuberculosis Program, School of Medicine, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco 255, Centro de Pesquisa em Tuberculose 4 andar, Ilha do Fund?o. CEP 21941-913, Rio de Janeiro, RJ, Brazil
3. Ary Parreiras Institute—Rio de Janeiro State Secretary of Health, Rio de Janeiro, Brazil
4. Santa Maria Hospital—Rio de Janeiro State Secretary of Health, Rio de Janeiro, Brazil
5. School of Medicine of Ribeir?o Preto, University of S?o Paulo, S?o Paulo, Brazil
6. Institute of Physics, Rio de Janeiro State University, Rio de Janeiro, Brazil - ISSN：1559-0720
文摘
Iron, copper, and zinc are key micronutrients that play an important role in the immune response to Mycobacterium tuberculosis. The present study aimed to evaluate the association between serum levels of those micronutrients, inflammatory markers, and the smear and culture conversion of M. tuberculosis during 60?days of tuberculosis treatment. Seventy-five male patients with pulmonary tuberculosis (mean age, 40.0?±-0.7?years) were evaluated at baseline and again at 30 and 60?days of tuberculosis treatment. Serum levels of iron, copper, zinc, albumin, globulin, C-reactive protein, and hemoglobin, and smear and cultures for M. tuberculosis in sputum samples were analyzed. Compared to healthy subjects, at baseline, patients with PTB had lower serum iron levels, higher copper levels and copper/zinc ratio, and similar zinc levels. During the tuberculosis treatment, no significant changes in the serum levels of iron, zinc, and copper/zinc were observed. Lower serum copper levels were associated with bacteriological conversion in tuberculosis treatment (tuberculosis-negative) at 30?days but not at 60?days (tuberculosis-positive). C-reactive protein levels and the C-reactive protein/albumin ratio were lower in tuberculosis-negative patients than in tuberculosis-positive patients at 30 and 60?days after treatment. Albumin and hemoglobin levels and the albumin/globulin ratio in patients with pulmonary tuberculosis increased during the study period, regardless of the bacteriological results. High serum globulin levels did not change among pulmonary tuberculosis patients during the study. Serum copper levels and the C-reactive protein/albumin ratio may be important parameters to evaluate the persistence of non-conversion after 60?days of tuberculosis treatment, and they may serve as predictors for relapse after successful treatment.