Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model
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- 作者：Michael R. La Frano ; Johannes F. Fahrmann ; Dmitry Grapov ; Oliver Fiehn…
- 关键词：Metabolomics ; Lipid mediators ; Pulmonary hypertension ; Bronchopulmonary dysplasia ; Hyperoxia ; Growth restriction
- 刊名：Metabolomics
- 出版年：2017
- 出版时间：April 2017
- 年：2017
- 卷：13
- 期：4
- 全文大小：
- 刊物主题：Biochemistry, general; Molecular Medicine; Cell Biology; Developmental Biology; Biomedicine, general;
- 出版者：Springer US
- ISSN：1573-3890
- 卷排序：13
文摘
IntroductionNeonatal pulmonary hypertension (PH) is a common manifestation of bronchopulmonary dysplasia (BPD) and contributes to increased morbidity and mortality of preterm birth. Postnatal growth restriction (PNGR) and hyperoxia are independent contributors to PH development, as indicated by our previous work in a rat model of BPD.