Distinct patterns of medial temporal impairment in degenerative dementia: a brain SPECT perfusion study in Alzheimer’s disease and frontotemporal dementia

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• 作者：Mathieu Basely (1)
  Mathieu Ceccaldi (2) (3)
  Laurent Boyer (4)
  Olivier Mundler (5) (6)
  Eric Guedj (5) (6) (7)
  
• 关键词：Brain SPECT ; Medial temporal lobe ; Alzheimer’s disease ; Frontotemporal dementia ; Compensation
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：40
• 期：6
• 页码：932-942
• 全文大小：537KB
• 参考文献：1. Belmin J, Péquignot R, Konrat C, Pariel-Madjlessi S. Prise en charge de la maladie d’Alzheimer. Presse Med. 2007;36:1500-0. CrossRef
  2. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl). 1991;82:239-6. CrossRef
  3. Gomez-Isla T, Price TL, McKeel DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J Neurosci. 1997;16:4491-00.
  4. Duyckaerts C, Colle MA, Dessi F, Grignon Y, Piette F, Hauw JJ. The progression of the lesions in Alzheimer disease: insights from a prospective clinicopathological study. J Neural Transm Suppl. 1998;53:119-6. CrossRef
  5. Nagy Z, Jobst KA, Esiri MM, Morris JH, King EM, McDonald B, et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer’s disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia. 1996;7:76-1.
  6. Squire LR, Stark CEL, Clark RE. The medial temporal lobe. Annu Rev Neurosci. 2004;27:279-06. CrossRef
  7. Spiers HJ, Maguire EA, Burgess N. Hippocampal amnesia. Neurocase. 2001;7:357-2. CrossRef
  8. Van der Linden M, Coyette F, Poitrenaud J, Kalafat M, Calicis F, Wyns C, et al. L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI-16). In: Van der Linden M, editor. L’évaluation des troubles de la mémoire. Marseille: Solal; 2004. p. 25-8.
  9. de Leon MJ, Golomb J, George AE, Convit A, Tarshish CY, McRae T, et al. The radiologic prediction of Alzheimer’s disease: the atrophic hippocampal formation. Am J Neuroradiol AJNR. 1993;14:897-06.
  10. Baron JC, Chételat G, Desganges B, Perchey G, Landeau B, de la Sayette V, et al. In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease. Neuroimage. 2001;14:298-09. CrossRef
  11. Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer’s disease. Lancet. 1994;344:895. CrossRef
  12. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Ann Neurol. 1997;42:85-4. CrossRef
  13. Johnson KA, Jones BL, Holman JA, Becker JA, Spiers PA, Satlin A, et al. Preclinical prediction of Alzheimer’s disease using SPECT. Neurology. 1998;50:1563-1. CrossRef
  14. Kogure D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T, et al. Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT. J Nucl Med. 2000;41:1155-2.
  15. Matsuda H, Kanetaka H, Ohnishi T, Asada T, Imabayashi E, Nakano S, et al. Brain SPET abnormalities in Alzheimer’s disease before and after atrophy correction. Eur J Nucl Med Mol Imaging. 2002;29:1502-. CrossRef
  16. Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer’s disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging. 2005;32:486-10. CrossRef
  17. Morbelli S, Piccardo A, Villavecchia G, Dessi B, Brugnolo A, Piccini A, et al. Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study. Eur J Nucl Med Mol Imaging. 2010;37:36-5. CrossRef
  18. Chételat G, Desgranges B, Eustache F. Brain profile of hypometabolism in early Alzheimer’s disease: relationships with cognitive deficits and atrophy. Rev Neurol. 2006;162:945-1. CrossRef
  19. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology. 1984;34:939-4. CrossRef
  20. Neary D, Snowden JS, Mann D. Frontotemporal dementia. Lancet Neurol. 2005;4:771-0. CrossRef
  21. Le Ber I, Camuzat A, Hannequin D, Pasquier F, Guedj E, Rovelet-Lecrux A, et al. Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study. Brain. 2008;131:732-6. CrossRef
  22. Deloche G, Hannequin D. Test de dénomination oral d’images, DO 80. Paris: Edition du Centre de psychologie appliquée; 1997.
  23. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activation in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15:273-9. CrossRef
  24. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19:1233-. CrossRef
  25. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60:1119-2. CrossRef
  26. Delacourte A, Campion D, Davous P. Maladie d’Alzheimer. EMC (Elsevier Masson SAS, Paris) Neurologie; 2007. 17-056-A-15.
  27. Deramecourt V, Lebert F, Pasquier F. Démences frontotemporales. EMC (Elsevier Masson SAS, Paris) Neurologie; 2007. 17-057-A-30.
  28. Sarazin M, Berr C, De Rotrou J, Fabrigoule C, Pasquier F, Legrain S, et al. Amnestic syndrome of the medial temporal type identifies prodromal AD. Neurology. 2007;69:1859-7. CrossRef
  29. Derouesné C, Lacomblez L. Sémiologie des troubles de la mémoire. EMC (Elsevier Masson SAS, Paris) Psychiatrie; 2007. 37-115-A-10.
  30. Le Ber I, Guedj E, Gabelle A, Verpillat P, Volteau M, Thomas-Anterion C, et al. Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia. Brain. 2006;129:3051-5. CrossRef
  31. Van de Pol LA, Hensel A, Van der Flier WM, Visser PJ, Pijnenburg YAL, Barkhof F, et al. Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer’s disease. Neurol Neurosurg Psychiatr. 2006;77:439-2. CrossRef
  32. Mayeux R. Alzheimer’s disease: epidemiology. Handb Clin Neurol. 2008;89:195-05. CrossRef
  33. Bornebroek M, Breteler M. Epidemiology of non-AD dementias. Clin Neurosci Res. 2004;3:349-1. CrossRef
  34. Kennedy PJ, Shapiro ML. Retrieving memories via internal concept requires the hippocampus. J Neurosci. 2004;24:6979-5. CrossRef
  35. Tounsi H, Deweer B, Ergis AM, Van Der Linden M, Pillon B, Michon A, et al. Sensitivity to semantic cuing: an index of episodic memory dysfunction in early Alzheimer disease. Alzheimer Dis Assoc Disord. 1999;13:38-6. CrossRef
  36. Rodriguez G, Vitali P, Calvini P, Bordoni C, Girtler N, Taddei G, et al. Hippocampal perfusion in mild Alzheimer’s disease. Psychiatr Res. 2000;100:65-4. CrossRef
  37. Nebu A, Ikeda M, Fukuhara R, Komori K, Maki N, Hokoishi K, et al. Utility of (99m)Tc-HM-PAO SPECT hippocampal image to diagnose early stages of Alzheimer’s disease using semiquantitative analysis. Dement Geriatr Cogn Disord. 2001;12:153-. CrossRef
  38. Elgh E, Sundstrom T, Nasman B, Ahlstrom R, Nyberg L. Memory functions and rCBF (99m)Tc-HMPAO SPET: developing diagnostics in Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2002;29:1140-. CrossRef
  39. Alsop DC, Casement M, de Bazelaire C, Fong T, Press DZ. Hippocampal hyperperfusion in Alzheimer’s disease. Neuroimage. 2008;42:1267-4. CrossRef
  40. Laakso MP, Frisoni GB, K?n?nen M, Mikkonen M, Beltramello A, Geroldi C, et al. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056-3. CrossRef
  41. Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer’s Disease". The Ronald and Nancy Reagan Research Institute on Aging Working Group. Neurobiol Aging. 1998;19:109-6.
  42. McNeill R, Sare GM, Manoharan M, Testa HJ, Mann DMA, Neary D, et al. Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2007;78:350-. CrossRef
  43. Dougall NJ, Bruggink S, Ebmeier KP. Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia. Am J Geriatr Psychiatr. 2004;12:554-0.
  44. Bonte FJ, Harris TS, Roney CA, Hynan LS. Differential diagnosis between Alzheimer’s and frontotemporal disease by the posterior cingulated sign. J Nucl Med. 2004;45:771-.
  45. Matsuda H, Kitayama N, Ohnishi T, Asada T, Nakano S, Sakamoto S, et al. Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer’s disease. J Nucl Med. 2002;43:304-1.
  46. Caroli A, Geroldi C, Nobili F, Barnden LR, Guerra UP, Bonetti M, et al. Functional compensation in incipient Alzheimer’s disease. Neurobiol Aging. 2010;31:387-7. CrossRef
  47. Chételat G, Desgranges B, Landeau B, Mezenge F, Poline JB, de la Sayette V, et al. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer’s disease. Brain. 2008;131:60-1. CrossRef
  48. Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC, et al. Patterns of brain activation in people at risk for Alzheimer’s disease. N Engl J Med. 2000;343:450-. CrossRef
  49. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005;65:404-1. CrossRef
  50. Guedj E, Barbeau EJ, Didic M, Felician O, de Laforte C, Ranjeva JP, et al. Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation? Eur J Nucl Med Mol Imaging. 2009;36:1101-2. CrossRef
  51. Broe M, Hodges JR, Schofield E, Shepherd CE, Kril JJ, Halliday GM. Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology. 2003;60:1005-1. CrossRef
  52. Thal DR, Rüb U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology. 2002;58:1791-00. CrossRef
  53. Broe M, Kril J, Halliday GM. Astrocytic degeneration relates to the severity of disease in frontotemporal dementia. Brain. 2004;127:2214-0. CrossRef
  54. Araque A, Sanzgiri RP, Parpura V, Haydon PG. Astrocyte-induced modulation of synaptic transmission. Can J Physiol Pharmacol. 1999;77:699-06. CrossRef
  55. Libby LA, Ekstrom AD, Ragland JD, Ranganath C. Differential connectivity of perirhinal and parahippocampal cortices within human hippocampal subregions revealed by high-resolution functional imaging. J Neurosci. 2012;32:6550-0. CrossRef
  
• 作者单位：Mathieu Basely (1)
  Mathieu Ceccaldi (2) (3)
  Laurent Boyer (4)
  Olivier Mundler (5) (6)
  Eric Guedj (5) (6) (7)
  
  1. Service de Médecine Nucléaire, H?pital d’Instruction des Armées Sainte Anne, 83800, Toulon Cedex 09, France
  2. Service de Neurologie et de Neuropsychologie, APHM, H?pital de la Timone, Marseille, France
  3. UMR Inserm 1106, Institut de Neurosciences des Systèmes, Aix-Marseille Univ, 13005, Marseille, France
  4. EA 3279 - Self-perceived Health Assessment Research Unit, School of Medicine, La Timone University, 13005, Marseille, France
  5. Service Central de Biophysique et Médecine Nucléaire, APHM, H?pital de la Timone, Pierre, 13385, Marseille Cedex 05, France
  6. CERIMED, Aix-Marseille Univ, Marseille, France
  7. Institut de Neurosciences de la Timone, CNRS UMR7289, Aix-Marseille Univ, 13005, Marseille, France
  
• ISSN：1619-7089

文摘

Purpose Medial temporal impairment can be detected clinically and by morphological imaging during Alzheimer’s disease (AD), but the existence of a functional impairment in this area seems to be less well established. Yet such functional impairment is classically found in other degenerative cortical dementias, such as the frontal variant of frontotemporal dementia (fv-FTD). The aim of this study was to characterize and compare brain SPECT perfusion of the medial temporal lobe in AD and fv-FTD. Methods Voxel-based comparisons were performed using SPM8 between cerebral SPECT images from 85?AD patients, 25 fv-FTD patients and 12 healthy controls at the whole-brain level and the medial temporal lobe level using a region of interest approach (p-lt;-.001, corrected for the cluster). Results In the free and cued selective reminding test, used to evaluate medial temporal memory function, AD patients had significantly lower scores than the fv-FTD patients (p-lt;-.005). AD and fv-FTD patients showed hypoperfused medial temporal structures in comparison to normal controls. However, fv-FTD patients had more pronounced hypoperfusion in this area, with a different topography, more anterior and more parahippocampal. Conclusion These results show that medial temporal hypoperfusion can be detected in degenerative dementias by SPECT. Paradoxically, the hypoperfusion is more severe in fv-FTD than in AD patients, even though the mnesic profile of AD is more altered, suggesting the existence of inefficient compensatory mechanisms.