Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism
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- 作者：Natalie L. Trevaskis ; David M. Shackleford ; William N. Charman ; Glenn A. Edwards ; Anne Gardin ; Silke Appel-Dingemanse ; Olivier Kretz ; Bruno Galli and Christopher J. H. Porter
- 关键词：KEY WORDS cannabinoid ; first ; pass metabolism ; food effect ; lymphatic transport ; oral bioavailability
- 刊名：Pharmaceutical Research
- 出版年：2009
- 出版时间：June, 2009
- 年：2009
- 卷：26
- 期：6
- 页码：1486-1495
- 全文大小：184.7 KB
文摘
Purpose To examine the effect of food on the oral bioavailability of a highly lipophilic, cannabinoid receptor agonist (CRA13) and to explore the basis for the food effect in lymph-cannulated and non-cannulated dogs.