Age-related synaptic loss of the medial olivocochlear efferent innervation
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- 作者：Benjamin Fu (1)
Colleen Le Prell (2)
Dwayne Simmons (3)
Debin Lei (1)
Angela Schrader (1)
Amelia B Chen (1)
Jianxin Bao (1) (4) (5) - 刊名：Molecular Neurodegeneration
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：5
- 期：1
- 全文大小：1373KB
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Colleen Le Prell (2)
Dwayne Simmons (3)
Debin Lei (1)
Angela Schrader (1)
Amelia B Chen (1)
Jianxin Bao (1) (4) (5)
1. Department of Otolaryngology, Washington University, 63110, St. Louis, MO, USA
2. Department of Communicative Disorders, Speech and Hearing Center, University of Florida, 32610, Gainesville, FL, USA
3. Department of Physiological Science, Brain Research Institute UCLA, 90095, Los Angeles, CA, USA
4. Center for Aging, Washington University, 63110, St. Louis, MO, USA
5. The Division of Biology & Biomedical Science and Neuroscience Program, Washington University, 63110, St. Louis, MO, USA
文摘
Age-related functional decline of the nervous system is consistently observed, though cellular and molecular events responsible for this decline remain largely unknown. One of the most prevalent age-related functional declines is age-related hearing loss (presbycusis), a major cause of which is the loss of outer hair cells (OHCs) and spiral ganglion neurons. Previous studies have also identified an age-related functional decline in the medial olivocochlear (MOC) efferent system prior to age-related loss of OHCs. The present study evaluated the hypothesis that this functional decline of the MOC efferent system is due to age-related synaptic loss of the efferent innervation of the OHCs. To this end, we used a recently-identified transgenic mouse line in which the expression of yellow fluorescent protein (YFP), under the control of neuron-specific elements from the thy1 gene, permits the visualization of the synaptic connections between MOC efferent fibers and OHCs. In this model, there was a dramatic synaptic loss between the MOC efferent fibers and the OHCs in older mice. However, age-related loss of efferent synapses was independent of OHC status. These data demonstrate for the first time that age-related loss of efferent synapses may contribute to the functional decline of the MOC efferent system and that this synaptic loss is not necessary for age-related loss of OHCs.