Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life

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• 作者：Prof. Dr. Marlies Knipper ; Rama Panford-Walsh ; Wibke Singer…
• 关键词：Inner hair cell ; Auditory neuropathy ; Tinnitus ; Hyperacusis ; Auditory cortex
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：361
• 期：1
• 页码：77-93
• 全文大小：8,362 KB
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• 作者单位：Prof. Dr. Marlies Knipper (1)
  Rama Panford-Walsh (2)
  Wibke Singer (1)
  Lukas R眉ttiger (1)
  Ulrike Zimmermann (1)
  
  1. Department of Otolaryngology, Head and Neck Surgery, T眉bingen Hearing Research Center (THRC), Molecular Physiology of Hearing, University of T眉bingen, Elfriede-Aulhorn-Stra脽e 5, 72076, T眉bingen, Germany
  2. DNA Genotek, 2 Beaverbrook Road, Kanata, ON, K2K 1L1, Canada
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Before hearing onset, inner hair cell (IHC) maturation proceeds under the influence of spontaneous Ca2+ action potentials (APs). The temporal signature of the IHC Ca2+ AP is modified through an efferent cholinergic feedback from the medial olivocochlear bundle (MOC) and drives the IHC pre- and post-synapse phenotype towards low spontaneous (spike) rate (SR), high-threshold characteristics. With sensory experience, the IHC pre- and post-synapse phenotype matures towards the instruction of low-SR, high-threshold and of high-SR, low-threshold auditory fiber characteristics. Corticosteroid feedback together with local brain-derived nerve growth factor (BDNF) and catecholaminergic neurotransmitters (dopamine) might be essential for this developmental step. In this review, we address the question of whether the control of low-SR and high-SR fiber characteristics is linked to various degrees of vulnerability of auditory fibers in the mature system. In particular, we examine several IHC synaptopathies in the context of various hearing disorders and exemplified shortfalls before and after hearing onset.