Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer's disease
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- 作者：Jae Sue Choi ; Himanshu Kumar Bhakta ; Hajime Fujii…
- 关键词：Oligonol ; Anti ; diabetic activity ; Anti ; Alzheimer activity ; Kinetics
- 刊名：Archives of Pharmacal Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：39
- 期：3
- 页码：409-420
- 全文大小：643 KB
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Himanshu Kumar Bhakta (1)
Hajime Fujii (2)
Byung-Sun Min (3)
Chan Hum Park (3)
Takako Yokozawa (4)
Hyun Ah Jung (5)
1. Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea
2. Amino Up Chemical Company, Ltd., Sapporo, Japan
3. College of Pharmacy, Catholic University of Daegu, Gyeongbuk, 712-702, Republic of Korea
4. Graduate School of Science and Engineering for Research, University of Toyama, Toyama, 930-8555, Japan
5. Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, 561-756, Republic of Korea - 刊物主题：Pharmacy; Pharmacology/Toxicology;
- 出版者：Springer Netherlands
- ISSN：1976-3786
文摘
Oligonol is a low-molecular-weight form of polyphenol that is derived from lychee fruit extract and contains catechin-type monomers and oligomers of proanthocyanidins. This study investigates the anti-diabetic activities of oligonol via α-glucosidase and human recombinant protein tyrosine phosphatase 1B (PTP1B) assays, as well as its anti-Alzheimer activities by evaluating the ability of this compound to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Oligonol exhibited potent concentration-dependent anti-diabetic activities by inhibiting α-glucosidase and PTP1B with IC50 values of 23.14 µg/mL and 1.02 µg/mL, respectively. Moreover, a kinetics study revealed that oligonol inhibited α-glucosidase (K i = 22.36) and PTP1B (K i = 8.51) with characteristics typical of a mixed inhibitor. Oligonol also displayed potent concentration-dependent inhibitory activity against AChE and BChE with IC50 values of 4.34 µg/mL and 2.07 µg/mL, respectively. However, oligonol exhibited only marginal concentration-dependent BACE1 inhibitory activity with an IC50 value of 130.45 µg/mL. A kinetics study revealed mixed-type inhibition against AChE (K i = 4.65) and BACE1 (K i = 58.80), and noncompetitive-type inhibition against BChE (K i = 9.80). Furthermore, oligonol exhibited dose-dependent inhibitory activity against peroxynitrite (ONOO−)-mediated protein tyrosine nitration. These results indicate that oligonol has strong preventative potential in diabetes mellitus and in Alzheimer’s disease.