The 7-valent pneumococcal conjugate vaccine elicits cross-functional opsonophagocytic killing responses to Streptococcus pneumoniae serotype 6D in children
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- 作者：Hyunju Lee (4) (5)
Jung Hwa Cha (5)
Moon H Nahm (5)
Robert L Burton (5)
Kyung-Hyo Kim (4) (5) - 关键词：Streptococcus pneumoniae ; Heptavalent pneumococcal conjugate vaccine ; Pneumococcal polysaccharide type 6
- 刊名：BMC Infectious Diseases
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：223 KB
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36. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/474/prepub - 作者单位：Hyunju Lee (4) (5)
Jung Hwa Cha (5)
Moon H Nahm (5)
Robert L Burton (5)
Kyung-Hyo Kim (4) (5)
4. Center for Vaccine Evaluation and Study, Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea
5. Departments of Pathology and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA - ISSN：1471-2334
文摘
Background We investigated the immune response to serogroup 6 with the opsonophagocytic killing assay (OPKA) in children aged 12-3 months of age after immunization with the 7-valent pneumococcal conjugate vaccine (PCV7) containing serotype 6B. Methods Blood samples were obtained from 59 children who had blood sampling for medical examination. Immunization status against PCV7 was confirmed by immunization records and samples were categorized according to immunization status into a booster, primary, or control group. The OPKA was performed for serotypes 6A, 6B, 6C, and 6D. Results Subjects with no previous PCV7 immunization history showed opsonic activity for serogroup 6 in 5-30% (according to serotype). In subjects vaccinated with a 3-dose primary series, 81% showed opsonic activity for serotypes 6B and 6D, and 29% showed opsonic activity for serotypes 6A and 6C. Among subjects vaccinated with a booster dose, all subjects had opsonic activity against serotype 6B. Subjects in the booster group with opsonic activity against serotypes 6A, 6C, and 6D were 100%, 78%, and 89%, respectively. Conclusions In subjects aged 12-3 months, an immune response is elicited after a primary series of immunizations with PCV7 for serotypes 6B and 6D, and a booster dose enhances a cross reactive immune response against serotypes 6A, 6C and 6D.