Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

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• 作者：Li-Rong Shen (1) (2)
  Fa Xiao (1)
  Peng Yuan (1)
  Ying Chen (1)
  Qi-Kang Gao (1)
  Laurence D. Parnell (2)
  Mohsen Meydani (3)
  Jose M. Ordovas (2)
  Duo Li (1)
  Chao-Qiang Lai (2)
  
• 关键词：Curcumin ; Lifespan ; MDA ; SOD ; Age ; related genes
• 刊名：AGE
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：35
• 期：4
• 页码：1133-1142
• 全文大小：337KB
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• 作者单位：Li-Rong Shen (1) (2)
  Fa Xiao (1)
  Peng Yuan (1)
  Ying Chen (1)
  Qi-Kang Gao (1)
  Laurence D. Parnell (2)
  Mohsen Meydani (3)
  Jose M. Ordovas (2)
  Duo Li (1)
  Chao-Qiang Lai (2)
  
  1. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, 310058, China
  2. Nutrition and Genomics Lab, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
  3. Vascular Biology Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
  

文摘

Curcumin is a polyphenolic bioactive compound in turmeric. We examined if antioxidant effects of curcumin are associated with lifespan extension in Drosophila. In this experiment, females and males of Drosophila were fed diets either containing no curcumin (C0) or supplemented with curcumin at 0.5 (C1) and 1.0 (C2) mg/g of diet. The levels of malondialdehyde (MDA), enzyme activity of superoxide dismutase (SOD), and expression of seven age-related genes in females and males were analyzed. We found that C1 and C2 increased mean lifespan by 6.2?% and 25.8?% in females, and by 15.5?% and 12.6?% in males, respectively. Meanwhile, C1 and C2 significantly decreased MDA levels and increased SOD activity in both genders. Diets C1 in females and C2 in males are effective in extending mean lifespan and improving levels of two physiological and biochemical measures related to aging in Drosophila. Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes. The present results suggest that curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation. This study provided new insights for understanding the anti-aging mechanism of curcumin in Drosophila.