The influence of chorionic gonadotropin and estriol on NK cell phenotype and functional activity
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- 作者：S. V. Shirshev ; I. V. Nekrasova ; O. L. Gorbunova ; E. G. Orlova
- 关键词：NK cells ; chorionic gonadotropin ; estriol ; cytokines
- 刊名：Human Physiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：42
- 期：5
- 页码：554-558
- 全文大小：297 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Life Sciences
Human Physiology
Biomedicine
Russian Library of Science - 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
- ISSN：1608-3164
- 卷排序：42
文摘
The influence of chorionic gonadotropin (CG) and estriol (Е3) at the concentrations typical of pregnancy on the expression of phenotypic markers and cytokine production by separated NK cells has been studied. It has been found that these hormones increase the percentage of CD56bright L-selectin+ NK cells, but also stimulate the expression of the inhibitory molecule NKG2A in the lymphocytes. In addition, Е3 and CG stimulate the production of TGF-β, inhibiting the secretion of all other cytokines by separated NK cells. In general, these hormones contribute to the formation of the phenotype and cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells during pregnancy.