The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor

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• 作者：Raef FA Hafez (1)
  Magad S Morgan (1)
  Osama M Fahmy (1)
  
• 刊名：World Journal of Surgical Oncology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：8
• 期：1
• 全文大小：774KB
• 参考文献：1. Lisc谩k R, Vladyka V, Wowra B, Kemeny A, Forster D, Burzaco JA, Martinez R, Eustacchio S, Pendl G, Regis J, Pellet W: Gamma Knife radiosurgery of the glomus jugulare tumour - early multicentre experience. / Acta Neurochir (Wien) 1999, 141: 1141鈥?146. CrossRef
  2. Gottfried ON, Liu JK, Couldwell WT: Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. / Neurosurg Focus 2004, 17 (2) : E4. CrossRef
  3. Jordan JA, Roland PS, McManus C, Weiner RL, Giller CA: Stereotastic radiosurgery for glomus jugulare tumors. / Laryngoscope 2000, 110: 35鈥?8. CrossRef
  4. Lim M, Bower R, Nangiana JS, Adler JR, Chang SD: Radiosurgery for glomus jugulare tumors. / Technol Cancer Res Treat 2007, 6 (5) : 419鈥?23.
  5. Varma A, Nathoo N, Neyman G, Suh JH, Ross J, Park J, Barnett GH: Gamma knife radiosurgery for glomus jugulare tumors: volumetric analysis in 17 patients. / Neurosurgery 2006, 59 (5) : 1030鈥?036. discussion 1036
  6. Fayad JN, Schwartz MS, Brackmann DE: Treatment of recurrent and residual glomus jugulare tumors. / Skull Base 2009, 19 (1) : 92鈥?8. CrossRef
  7. Guss ZD, Batra S, Li G, Chang SD, Parsa AT, Rigamonti D, Kleinberg L, Lim M: Radiosurgery for glomus jugulare: history and recent progress. / Neurosurg Focus 2009, 27 (6) : E5. CrossRef
  8. Ganz JC, Abdelkarim K: Glomus jugulare tumours: certain clinical and radiological aspects observed following Gamma Knife radiosurgery. / Acta Neurochir (Wien) 2009, 151 (5) : 423鈥?26. CrossRef
  9. Gerosa M, Visca A, Rizzo P, Foroni R, Nicolato A, Bricolo A: Glomus jugulare tumors: the option of gamma knife radiosurgery. / Neurosurgery 2006, 59 (3) : 561鈥?69. CrossRef
  10. Green JD Jr, Brackmann DE, Nguyen CD, Arriaga MA, Telischi FF, De la Cruz A: Surgical management of previously untreated glomus jugulare tumors. / Laryngoscope 1994, 104: 917鈥?21.
  11. Sharma MS, Gupta A, Kale SS, Agrawal D, Mahapatra AK, Sharma BS: Gamma knife radiosurgery for glomus jugulare tumors: therapeutic advantages of minimalism in the skull base. / Neurol India 2008, 56 (1) : 57鈥?1. CrossRef
  12. Sheehan J, Kondziolka D, Flickinger J, Lunsford LD: Gamma knife surgery for glomus jugulare tumors: an intermediate report on efficacy and safety. / J Neurosurg 2005, 102 (Suppl) : 241鈥?46. CrossRef
  13. Patel SJ, Sekhar LN, Cass SP, Hirsch BE: Combined approaches for resection of extensive glomus jugulare tumors. A review of 12 cases. / J Neurosurg 1994, 80: 1026鈥?038. CrossRef
  14. Pollock BE: Stereotactic radiosurgery in patients with glomus jugulare tumors. / Neurosurg Focus 2004, 17 (2) : E10. CrossRef
  15. Watkins LD, Mendoza N, Cheesman AD, Symon L: Glomus jugulare tumors: a review of 61 cases. / Acta Neurochir (Wien) 1994, 130: 66鈥?0. CrossRef
  16. Eustacchio S, Trummer M, Unger F, Schrottner O, Sutter B, Pendl G: The role of Gamma Knife radiosurgery in the management of glomus jugular tumors. / Acta Neurochir Suppl 2002, 84: 91鈥?7.
  17. Schild SE, Foote RL, Buskirk SJ, Robinow JS, Bock FF, Cupps RE, Earle JD: Results of radiotherapy for chemodectomas. / Mayo Clin Proc 1992, 67: 537鈥?40.
  
• 作者单位：Raef FA Hafez (1)
  Magad S Morgan (1)
  Osama M Fahmy (1)
  
  1. Neurosurgery and Gamma knife department, International Medical Center, Cairo, Egypt
  

文摘

Background Glomus jugulare is a slowly growing, locally destructive tumor located in the skull base with difficult surgical access. The operative approach is, complicated by the fact that lesions may be both intra and extradural with engulfment of critical neurovascular structures. The tumor is frequently highly vascular, thus tumor resection entails a great deal of morbidity and not infrequent mortality. At timeslarge residual tumors are left behind. To decrease the morbidity associated with surgical resection of glomus jugulare, gamma knife surgery (GKS) was performed as an alternative in 13 patients to evaluate its safety and efficacy. Methods A retrospective review of 13 residual or unresectable glomus jagulare treated with GKS between 2004 and 2008.. Of these, 11 patients underwent GKS as the primary management and one case each was treated for postoperative residual disease and postembolization. The radiosurgical dose to the tumor margin ranged between 12-15 Gy. Results Post- gamma knife surgery and during the follow-up period twelve patients demonstrated neurological stability while clinical improvement was achieved in 5 patients. One case developed transient partial 7th nerve palsy that responded to medical treatment. In all patients radiographic MRI follow-up was obtained, the tumor size decreased in two cases and remained stable (local tumor control) in eleven patients. Conclusions Gamma knife surgery provids tumor control with a lowering of risk of developing a new cranial nerve injury in early follow-up period. This procedure can be safely used as a primary management tool in patients with glomus jugulare tumors, or in patients with recurrent tumors in this location. If long-term results with GKS are equally effective it will emerge as a good alternative to surgical resection.