Osteoinductive potential of 4 commonly employed bone grafts

详细信息    查看全文

• 作者：Richard J. Miron ; Qiao Zhang ; Anton Sculean ; Daniel Buser…
• 关键词：Osteoinduction ; Osteoinductive potential ; Bone grafts ; Natural bone mineral
• 刊名：Clinical Oral Investigations
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：20
• 期：8
• 页码：2259-2265
• 全文大小：1,530 KB
• 刊物类别：Medicine
• 刊物主题：Dentistry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-3771
• 卷排序：20

文摘

ObjectivesGuided bone regeneration (GBR) aims to predictably restore missing bone that has been lost due to trauma, periodontal disease or a variety of systemic conditions. Critical to this procedure is the ability of a bone grafting material to predictably serve as a 3-dimensional scaffold capable of inducing cell and bone tissue in-growth at the material surface. Although all bone grafts are osteoconductive to bone-forming osteoblasts, only a small number of commercially available bone grafts with FDA approval are osteoinductive including demineralized freeze-dried bone allographs (DFDBA) and scaffolds containing bone morphogenetic proteins (BMPs). Recently, a class of synthetic bone grafts fabricated from biphasic calcium phosphate (BCP) sintered at a low temperature have been shown to form ectopic bone formation in non-skeletal sites without the use of growth factors. Therefore, the present study aimed to compare the osteoinductive potential of this group of synthetic BCP alloplasts with autografts, allografts and xenografts.