Stage-related treatment concept of medication-related osteonecrosis of the jaw—a case series

详细信息    查看全文

• 作者：Petra Rugani ; Stephan Acham ; Barbara Kirnbauer…
• 关键词：Antiresorptive therapy ; Jaws ; Medication ; related?osteonecrosis ; Treatment concept ; Surgical therapy
• 刊名：Clinical Oral Investigations
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：19
• 期：6
• 页码：1329-1338
• 全文大小：576 KB
• 参考文献：1.Ruggiero SL, Dodson TB, Fantasia J et al (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw-014 update. J Oral Maxillofac Surg 72:1938PubMed View Article
  2.Marx RE, Sawatari Y, Fortin M, Broumand V (2005) Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Maxillofacial Surg: Off J Am Assoc Oral Maxillofacial Surgeons 63(11):1567-575View Article
  3.Suleman YF, Meer S, Lurie R (2007) Bisphosphonate-induced osteonecrosis of the jaws: review, clinical implications and case report. Head Neck Pathol 1(2):156-64PubMed Central PubMed View Article
  4.Nicolatou-Galitis O, Migkou M, Psyrri A et al (2012) Gingival bleeding and jaw bone necrosis in patients with metastatic renal cell carcinoma receiving sunitinib: report of 2 cases with clinical implications. Oral Surg, Oral Med, Oral Pathol Oral Radiol 113(2):234-38View Article
  5.Ruggiero S, Gralow J, Marx RE et al (2006) Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer. J Oncol Pract / Am Soc Clin Oncol 2(1):7-4View Article
  6.Ruggiero SL, Fantasia J, Carlson E (2006) Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endodontics 102(4):433-41View Article
  7.Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB (2005) Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. J Am Dent Assoc 136(12):1658-668PubMed View Article
  8.Dickinson M, Prince HM, Kirsa S et al (2009) Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for prevention and treatment. Int Med J 39(5):304-16View Article
  9.Weitzman R, Sauter N, Eriksen EF et al (2007) Critical review: updated recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in cancer patients—May 2006. Crit Rev Oncol/Hematol 62(2):148-52View Article
  10.Abu-Id MH, Warnke PH, Gottschalk J et al (2008) “Bis-phossy jaws”—high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Cranio-Maxillo- Facial Surg: Off Publ Eur Assoc Cranio-Maxillo-Facial Surgery 36(2):95-03View Article
  11.Carlson ER, Basile JD (2009) Off J Am Assoc Oral Maxillofacial Surg 67(5 Suppl):85-5View Article
  12.Bedogni A, Saia G, Bettini G et al (2011) Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis. Oral Oncol 47(5):420-24PubMed View Article
  13.Biasotto M, Chiandussi S, Dore F et al (2006) Clinical aspects and management of bisphosphonates-associated osteonecrosis of the jaws. Acta Odontol Scand 64(6):348-54PubMed View Article
  14.Badros A, Weikel D, Salama A et al (2006) Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. J Clin Oncol Off J Am Soc Clin Oncol 24(6):945-52View Article
  15.Kühl S, Walter C, Acham S, Pfeffer R, Lambrecht JT (2012) Bisphosphonate-related osteonecrosis of the jaws—a review. Oral Oncol 48(10):938-7. doi:10.-016/?j.?oraloncology.-012.-3.-28 , Epub 2012 Apr 21PubMed View Article
  16.Rugani P, Acham S, Truschnegg A, Obermayer-Pietsch B, Jakse N (2010) Bisphosphonate-associated osteonecrosis of the jaws: surgical treatment with ErCrYSGG-laser. Case report. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endodontics 110(6):e1-View Article
  17.Filleul O, Crompot E, Saussez S (2010) Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases. J Cancer Res Clin Oncol 136(8):1117-124PubMed View Article
  18.Scoletta M, Arduino PG, Dalmasso P, Broccoletti R, Mozzati M (2010) Treatment outcomes in patients with bisphosphonate-related osteonecrosis of the jaws: a prospective study. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endodontics 110(1):46-3View Article
  19.Vescovi P, Merigo E, Meleti M, Manfredi M, Fornaini C, Nammour S (2012) Surgical approach and laser applications in BRONJ osteoporotic and cancer patients. J Osteoporos 2012:585434. doi:10.-155/-012/-85434 , Epub 2012 May 8PubMed Central PubMed View Article
  20.Pires FR, Miranda A, Cardoso ES et al (2005) Oral avascular bone necrosis associated with chemotherapy and biphosphonate therapy. Oral Dis 11(6):365-69PubMed View Article
  21.Abu-Id MH, Acil Y, Gottschalk J, Kreusch T (2006) Bisphosphonate-associated osteonecrosis of the jaw. Mund-, Kiefer- Und Gesichtschirurgie: MKG 10(2):73-1PubMed View Article
  22.Zarychanski R, Elphee E, Walton P, Johnston J (2006) Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol 81(1):73-5PubMed View Article
  23.Bagan J, Blade J, Cozar JM et al (2007) Recommen
• 作者单位：Petra Rugani (1)
  Stephan Acham (1)
  Barbara Kirnbauer (1)
  Astrid Truschnegg (1)
  Barbara Obermayer-Pietsch (2)
  Norbert Jakse (1)
  
  1. Department of Oral Surgery and Radiology, Medical University of Graz, Graz, Austria
  2. Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, Graz, Austria
  
• 刊物类别：Medicine
• 刊物主题：Dentistry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-3771

文摘

Objectives There is no general consensus for treatment of medication-related osteonecrosis of the jaw (MRONJ). A stage-related approach that primarily aims to minimize morbidity and preserve function was prospectively evaluated. Patients and methods Treatment goals are stable mucosal closure and absence of clinical symptoms. Patients were enrolled between March 2010 and October 2011. MRONJ lesions were treated either by conservative means or surgically by debridement or resective surgery. Results In total, 38 patients were treated. Six patients were healed by undergoing conservative measures; nine were treated palliatively. Four patients dropped out after surgery in the recall phase. In 17 of 19 patients (89.5?%) surgical treatment was successful. After a 1-year observation period, the success rate was 92?% (23 of 25), including all patients treated as per protocol. Conclusion In stage-related treatment, conservative means or surgical debridement can be successful at early stages. Extensive resection is solely indicated in cases of extended necrosis. Clinical relevance The number of patients with MRONJ is steadily increasing. Guidelines to deal with this condition are helpful for both clinicians and dental practitioners.