Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group
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- 作者：Amanda Psyrri ; Konstantine T. Kalogeras…
- 关键词：Osteopontin ; mRNA ; Breast cancer ; qRT ; PCR ; IHC ; Prognostic value ; Survival
- 刊名：Journal of Translational Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：1153KB
- 刊物主题：Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
- 卷排序：15
文摘
BackgroundThe shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk for relapse and metastatic spread and indicate the potential value of additional treatment strategies. Osteopontin (OPN) is a matricellular protein that has been suggested to be a potential biomarker in BC. In the present study, we used archived BC patient samples to assess the clinical utility of OPN.