TGF-β1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma

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• 作者：Zaijun Lin ; Dianwen Song ; Haifeng Wei…
• 关键词：miR ; 202 ; PDCD4 ; Drug resistance ; Osteosarcoma
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：142
• 期：1
• 页码：239-246
• 全文大小：1,435 KB
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• 作者单位：Zaijun Lin (1)
  Dianwen Song (1)
  Haifeng Wei (1)
  Xinghai Yang (1)
  Tielong Liu (1)
  Wangjun Yan (1)
  Jianru Xiao (1)
  
  1. Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Purpose A number of studies have demonstrated that microRNAs play a critical role in osteosarcoma progression, therapy and drug resistance. MicroRNA-202 has proven to be dysregulated in many human cancer studies. This study aimed to explore miR-202 contributions to drug resistance in osteosarcoma.