A comparative analysis of various antigenic proteins found in Haemonchus contortus—a review

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• 作者：I. R. Tak ; J. S. Dar ; S. A. Dar ; B. A. Ganai ; M. Z. Chishti ; F. Ahmad
• 关键词：Haemonchus contortus ; Ostertagia ostertagi ; vaccines ; anthelmintics ; sheep
• 刊名：Molecular Biology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：49
• 期：6
• 页码：789-795
• 全文大小：210 KB
• 参考文献：1.Newton S.E., Munn E.A. 1999. The development of vaccines against gastrointestinal nematode parasites, particularly Haemonchus contortus. Parasitol. Today. 15, 116-22.CrossRef PubMed
  2.Gilleard J.S. 2013. Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance. Parasitology. 140, 1506-522.CrossRef PubMed
  3.Jabbar A., Campbell A.J.D., Charles J.A., Gasser R.B. 2013. First report of anthelmintic resistance in Haemonchus contortus in alpacas in Australia. Parasit. Vectors. 6, 243.PubMedCentral CrossRef PubMed
  4.Areskog M., Sollenberg S., Engstrom A., Samson Himmelstjerna G., Hoglund J. 2014. A controlled study on gastrointestinal nematodes from two Swedish cattle farms showing field evidence of ivermectin resistance. Parasit. Vectors. 7, 13.PubMedCentral CrossRef PubMed
  5.Willadsen P. 1995. Commercialisation of a recombinant vaccine against Boophilus microplus. Parasitology. 110, 43-0.CrossRef
  6.Rickard M.D., Harrison G.B.L., Heath D.D., Lightowlers M.W. 1995. Taenia ovis recombinant vaccine—‘quo vadit- Parasitology. 110, 5-.CrossRef
  7.Smith W.D. 1999. Prospects for vaccines of helminth parasites of grazing ruminants. Int. J. Parasitol. 29, 17-4.CrossRef PubMed
  8.Knox D.P. 2000. Development of vaccines against gastro-intestinal nematodes. Parasitology. 120, 43-1.CrossRef
  9.Meyvis Y., Geldhof P., Gevaert K., Timmerman E., Vercruysse J., Claerebout E. 2007. Vaccination against Ostertagia ostertagi with subfractions of the protective ES-thiol fraction. Vet. Parasitol. 149, 239-45.CrossRef PubMed
  10.Molina J.M., Martin S., Hernandez Y.I., Gonzalez J.F., Ferrer O., Ruiz A. 2012. Immunoprotective effect of cysteine proteinase fractions from two Haemonchus contortus strains adapted to sheep and goats. Vet. Parasitol. 188, 53-9.CrossRef PubMed
  11.Soulsby E.J.L. 1987. Immune Responses in Parasitic Infections: Immunology, Immunopathology, and Immunoprophylaxis. Boca Raton, FL: CRC Press.
  12.Maere V.D., Vercauteren I., Gavaert K., Vercruysse J., Claerebout E. 2005. An aspartyl protease inhibitor of Ostertagia ostertagi: Molecular cloning, analysis of stage and tissue specific expression and vaccine trial. Mol. Biochem. Parasitol. 141, 81-8.CrossRef PubMed
  13.Meeusen E.N.T., Walker J., Peters A., Pastoret P.P., Jungersen G. 2007. Current status of veterinary vaccines. J. Clin. Microbiol. Rev. 20, 489-10.CrossRef
  14.Dalton J.P., Mulcahy G. 2001. Parasite vaccines: A reality? Vet. Parasitol. 98, 149-67.CrossRef PubMed
  15.Garcia-Coirades L., Angulo-Cubillan F., Valladares B., Martinez E., de la Feunte C., Alunda J.M., Cuquerella M. 2010. Immunization against lamb haemonchosis with a recombinant somatic antigen of Haemonchus contortus (rHcp26/23). Vet. Med. Intern. 2010, 852146.
  16.Wang W., Yuan C., Wang S., Song X., Xu L., Yan R., Hasson A., Li X. 2014. Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-regulated functions of goat PBMC and modulation of several signaling cascades in vitro. J. Proteomics. 98, 123-37.CrossRef PubMed
  17.Pengally C. 1999. Antiparasitics: Products and Markets. Animal Pharm Reports. London: PJB Publ.
  18.Zhan B., Hotez P.J., Wang Y., Hawdon J.M. 2002. A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Mol. Biochem. Parasitol. 120, 291-96.CrossRef PubMed
  19.McKeand J.B., Knox D.P., Duncan J.L., Kennedy M.W. 1995. Immunisation of guinea pigs against Dictyocaulus viviparus using adult ES products enriched for acetylcholinesterases. Int. J. Parasitol. 25, 829-37.CrossRef PubMed
  20.Brindley P.J., Kalinna B.H., Dalton J.P., Day S.R., Wong J.Y., Smythe M.L., McManus D.P. 1997. Proteolytic degradation of host haemoglobin by schistosomes. Mol. Biochem. Parasitol. 89, 1-.CrossRef PubMed
  21.Ghosh K., Hotez P.J. 1999. Antibody-dependent reductions in mouse hookworm burden after vaccination with Ancylostoma caninum secreted protein. J. Infect. Dis. 180, 1674-681.CrossRef PubMed
  22.Tort J., Brindley P.J., Knox D., Wolfe K.H., Dalton J.P. 1999. Proteinases and associated genes of parasitic helminths. Adv. Parasitol. 43, 161-66.CrossRef PubMed
  23.Knox D.P., Smith W.D. 2001. Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens. Vet. Parasitol. 100, 21-2.CrossRef PubMed
  24.Smith S.K., Pettit D., Newlands G.F., Redmond D.L., Skuce P.J., Knox D.P., Smith W.D. 1999. Further immunization and biochemical studies with a protective antigen complex from the microvillar membrane of the intestine of Haemonchus contortus. Parasite Immunol. 21, 187-99.CrossRef PubMed
  25.Knox D.P., Smith S.K., Smith W.D. 1999. Immunization with an affinity purified protein extract from the adult parasite protects lambs against infection with Haemonchus contortus. Parasite Immunol. 21, 201-10.CrossRef
• 作者单位：I. R. Tak (1)
  J. S. Dar (1)
  S. A. Dar (2)
  B. A. Ganai (1)
  M. Z. Chishti (1)
  F. Ahmad (3)
  
  1. Centre of Research for Development, University of Kashmir, Srinagar, 190006, India
  2. Department of Zoology, Punjabi University, Patiala, Punjabi, 147002, India
  3. Department of Zoology, University of Kashmir, Srinagar, 190006, India
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Life Sciences
  Biochemistry
  Human Genetics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3245

文摘

Many innovative researches on the development and introduction of recombinant vaccines against many economically important parasites were carried out in the 20th century. Research continues to hold promise with the development of immunological and molecular approaches for control of these parasites and in this regard it has already been seen that blood-sucking parasites such as Haemonchus contortus and Ostertagia ostertagi are susceptible to control by vaccines containing “novel-or “concealed-antigens. Haemonchus contortus is primarily pathogenic to sheep and its blood-feeding behaviour causes effects ranging from mild anaemia to mortality in young animals. Current means of control which are dependent on repeated treatment with anthelmintics are responsible for the increasing drug resistance of this parasite. Together with the growing concern of residual chemicals in the environment and food chain, this has led to attempts to better understand the biology of the parasite with an aim to develop alternate means of control, including the development of molecular vaccines. More problematic and also important is the formulation and delivery strategy to induce expulsion of this parasite, using vaccines containing recombinant “conventional-antigens. Tremendous progress has been made in the last decade in identifying several antigens from Haemonchus contortus which in their native form stimulate useful levels of protective immunity. Vaccines have been developed against H. contortus using ‘novel-gut antigens from the parasite, but variable responsiveness of the host sheep has resulted in varying degrees of protection which are stimulated by these vaccines. Computer models have also been used to simulate vaccine efficacy in worm control and have yielded good results. This review will try to summarise the protective efficacy and also the molecular properties of principal candidate antigens which are expressed by this parasite. The review will try to cover the aspirations, current success, limitations and problems faced by researchers in the control of this economically important parasite. Keywords Haemonchus contortus Ostertagia ostertagi vaccines anthelmintics sheep