Ultra-high resolution spectral domain optical coherence tomography using supercontinuum light source

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• 作者：Yiheng Lim ; Toyohiko Yatagai ; Yukitoshi Otani
• 关键词：Optical coherence tomography ; Supercontinuum ; Spectrometer calibration ; Sweat duct
• 刊名：Optical Review
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：23
• 期：2
• 页码：180-186
• 全文大小：1,782 KB
• 参考文献：1.Huang, D., Swanson, E., Lin, C., Schuman, J., Stinson, W., Chang, W., Hee, M., Flotte, T., Gregory, K., Puliafito, C., et al.: Optical coherence tomography. Science 254, 1178–1181 (1991)ADS CrossRef
  2.Gambichler, T., Pljakic, A., Schmitz, L.: Recent advances in clinical application of optical coherence tomography of human skin. Clin. Cosmet. Investig. Dermatol. 8, 345 (2015)CrossRef
  3.Welzel, J., Lankenau, E., Birngruber, R., Engelhardt, R.: Optical coherence tomography of the human skin. J. Am. Acad. Dermatol. 37, 958–963 (1997)CrossRef
  4.Lademann, J., Otberg, N., Richter, H., Meyer, L., Audring, H., Teichmann, A., Thomas, S., Knüttel, A., Sterry, W.: Application of optical non-invasive methods in skin physiology: a comparison of laser scanning microscopy and optical coherent tomography with histological analysis. Skin Res. Technol. 13, 119–132 (2007)CrossRef
  5.Kuo, W.C., Kuo, Y.M., Wen, S.Y.: Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography. J. Biophoton. (2015). doi:10.​1002/​jbio.​201400153
  6.Mogensen, M., Morsy, H., Nurnberg, B., Jemec, G.: Optical coherence tomography imaging of bullous diseases. J. Eur. Acad. Dermatol. Venereol. 22, 1458–1464 (2008)CrossRef
  7.Ohmi, M., Tanigawa, M., Wada, Y., Haruna, M.: Dynamic analysis for mental sweating of a group of eccrine sweat glands on a human fingertip by optical coherence tomography. Skin Res. Technol. 18, 378–383 (2012)CrossRef
  8.Tripathi, S.R., Miyata, E., Ishai, P.B., Kawase, K.: Morphology of human sweat ducts observed by optical coherence tomography and their frequency of resonance in the terahertz frequency region. Sci. Rep. 5, 9071 (2015)ADS CrossRef
  9.Leitgeb, R., Hitzenberger, C., Fercher, A.: Performance of fourier domain vs. time domain optical coherence tomography. Opt. Express 11, 889–894 (2003)ADS CrossRef
  10.Unterhuber, A., Povaay, B., Bizheva, K., Hermann, B., Sattmann, H., Stingl, A., Le, T., Seefeld, M., Menzel, R., Preusser, M., Budka, H., Schubert, C., Reitsamer, H., Ahnelt, P.K., Morgan, J.E., Cowey, A., Drexler, W.: Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography. Phys. Med. Biol. 49, 1235–1246 (2004)CrossRef
  11.Robles, F.E., Wilson, C., Grant, G., Wax, A.: Molecular imaging true-colour spectroscopic optical coherence tomography. Nat. Photonics 5, 744–747 (2011)ADS CrossRef
  12.Liu, L., Gardecki, J.A., Nadkarni, S.K., Toussaint, J.D., Yagi, Y., Bouma, B.E., Tearney, G.J.: Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat. Med. 17, 1010–1014 (2011)CrossRef
  13.Cimalla, P., Walther, J., Mehner, M., Cuevas, M., Koch, E.: Simultaneous dual-band optical coherence tomography in the spectral domain for high resolution in vivo imaging. Opt. Express 17, 19486 (2009)ADS CrossRef
  14.Yasuno, Y., Madjarova, V.D., Makita, S., Akiba, M., Morosawa, A., Chong, C., Sakai, T., Chan, K.-P., Itoh, M., Yatagai, T.: Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments. Opt. Express 13, 10652–10664 (2005)ADS CrossRef
  15.Wojtkowski, M., Srinivasan, V., Ko, T., Fujimoto, J., Kowalczyk, A., Duker, J.: Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Opt. Express 12, 2404–2422 (2004)ADS CrossRef
  
• 作者单位：Yiheng Lim (1)
  Toyohiko Yatagai (1)
  Yukitoshi Otani (1)
  
  1. Utsunomiya University, Utsunomiya, Tochigi, 321-8585, Japan
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Electromagnetism, Optics and Lasers
  
• 出版者：The Optical Society of Japan, co-published with Springer-Verlag GmbH
• ISSN：1349-9432

文摘

An ultra-high resolution spectral domain optical coherence tomography (SD-OCT) was developed using a cost-effective supercontinuum laser. A spectral filter consists of a dispersive prism, a cylindrical lens and a right-angle prism was built to transmit the wavelengths in range 680–940 nm to the OCT system. The SD-OCT has achieved 1.9 μm axial resolution and the sensitivity was estimated to be 91.5 dB. A zero-crossing fringes matching method which maps the wavelengths to the pixel indices of the spectrometer was proposed for the OCT spectral calibration. A double sided foam tape as a static sample and the tip of a middle finger as a biological sample were measured by the OCT. The adhesive and the internal structure of the foam of the tape were successfully visualized in three dimensions. Sweat ducts was clearly observed in the OCT images at very high resolution. To the best of our knowledge, this is the first demonstration of ultra-high resolution visualization of sweat duct by OCT.