Effects of Artichoke Extract Supplementation on Gonads of Cadmium-Treated Rats

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• 作者：Ebru Gurel (1) (5)
  Metin Caner (2)
  Levent Bayraktar (3)
  Nadim Yilmazer (4)
  Husniye Dogruman (3)
  Cihan Demirci (1)
  
• 关键词：Cadmium ; Artichoke ; eNOS ; iNOS ; Gonads
• 刊名：Biological Trace Element Research
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：119
• 期：1
• 页码：51-59
• 全文大小：800KB
• 参考文献：1. Waalkes MP (2003) Cadmium carcinogenesis. Mutat Res 533:107-20
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  10. Sen Gupta R, Kim J, Gomes C, Oh S, Park J, Im WB, Seong JY, Ahn RS, Kwon HB, Soh J (2004) Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Mol Cell Endocrinol 221:57-6 CrossRef
  11. Ilieva P, Khalkova ZH, Zaikov K, Kapurdov V, Ivanova-Chemishanska L (1994) The action of the artichoke ( / Cynara scolymus) on the male gonads in an experiment. Probl Khig 19:105-11
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• 作者单位：Ebru Gurel (1) (5)
  Metin Caner (2)
  Levent Bayraktar (3)
  Nadim Yilmazer (4)
  Husniye Dogruman (3)
  Cihan Demirci (1)
  
  1. Department of Biology, Istanbul University, Istanbul, Turkey
  5. Department of Biology, Faculty of Science, Istanbul University, 34459, Beyazit, Istanbul, Turkey
  2. Department of General Surgery, Istanbul University, Istanbul, Turkey
  3. Department of Medical Biology, Istanbul University, Istanbul, Turkey
  4. Biology Department, Terakki Foundation Schools, Istanbul, Turkey
  

文摘

The present study was designed to determine whether artichoke (Cynara scolymus) exerts a protective effect on gonads of cadmium-treated rats and if there is a relationship between artichoke supplementation and nitric oxide (NO) formation in cells. Forty Wistar albino male rats, weighing an average of 90?g each, were equally divided into four groups receiving 1?mg/100?g cadmium chloride by injection (group 1), the same dose CdCl2 plus 3?mg/100?g artichoke extract (group 2), the same dose of artichoke extract (group 3), and male controls (group 4). Four additional groups, labeled 5-, consisted of identically treated and control female rats. After 4?weeks of treatment, the animals were killed and their gonads were removed for histological examination. As expected, the seminiferous tubules and Leydig cells were damaged by cadmium. Ovarian tissue was not damaged to the same extent as testicular cells. Artichoke extract exerted a clear protective effect against Cd-induced testicular damage and lowered NO production to the same level of that in the control groups.