Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction

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• 作者：Tatiana Gorojankina
• 关键词：Smoothened ; Patched ; Gli ; Signal transduction ; PKA ; Sufu ; Crosstalk ; GPCR ; 7 ; DHC ; Oxysterol ; Primary cilium
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：73
• 期：7
• 页码：1317-1332
• 全文大小：876 KB
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• 作者单位：Tatiana Gorojankina (1) (2) (3) (4) (5)
  
  1. Neuroscience Paris-Saclay Institute (Neuro-PSI), UMR 9197, CNRS, Université Paris-Sud, Bât. 32/33, CNRS, 91190, Gif-sur-Yvette, France
  2. Institut Curie, Centre de Recherche, Orsay, France
  3. CNRS UMR3347, 91400, Orsay, France
  4. Univ. Paris Sud, Université Paris Saclay, Orsay, France
  5. INSERM U1021, 91400, Orsay, France
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning and stem cell maintenance. In spite of intensive study, the mechanisms of Hh signal transduction are not completely understood. Here I review published data and present a novel model of vertebrate Hh signaling suggesting that Smoothened (Smo) functions as a G-protein-coupled receptor in cilia. This is the first model to propose molecular mechanisms for the major steps of Hh signaling, including inhibition of Smo by Patched, Smo activation, and signal transduction from active Smo to Gli transcription factors. It also suggests a novel role for the negative pathway regulators Sufu and PKA in these processes.