文摘
The effect of cryogenic grinding on the indomethacin (IMC) and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry. Cryoground mixtures were shown to form glass solutions. PVP inhibits the crystallization of IMC from the amorphous state: the crystallization temperature of IMC in the mixtures with PVP increases, and the amorphous state is preserved longer on storage. The mixtures were characterized by Raman spectroscopy. Dissolution of the IMC in the cryoground mixtures is higher as compared to the pure form, also after a prolonged storage.