Grinding of drugs with pharmaceutical excipients at cryogenic temperatures

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• 作者：T. P. Shakhtshneider ; F. Danède ; F. Capet ; J. F. Willart ; M. Descamps ; L. Paccou ; E. V. Surov ; E. V. Boldyreva and V. V. Boldyrev
• 关键词：cryogrinding ; crystallization ; glass solution ; glass transition ; indomethacin ; polyvinylpyrrolidone
• 刊名：Journal of Thermal Analysis and Calorimetry
• 出版年：2007
• 出版时间：September, 2007
• 年：2007
• 卷：89
• 期：3
• 页码：709-715
• 全文大小：232 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Sciences
  Polymer Sciences
  Physical Chemistry
  Inorganic Chemistry
  Measurement Science and Instrumentation
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1572-8943

文摘

The effect of cryogenic grinding on the indomethacin (IMC) and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry. Cryoground mixtures were shown to form glass solutions. PVP inhibits the crystallization of IMC from the amorphous state: the crystallization temperature of IMC in the mixtures with PVP increases, and the amorphous state is preserved longer on storage. The mixtures were characterized by Raman spectroscopy. Dissolution of the IMC in the cryoground mixtures is higher as compared to the pure form, also after a prolonged storage.