Direct Electrical Stimulation Using a Battery-Operated Device for Induction and Modulation of Colonic Contractions in Pigs

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• 作者：Mattia Bertschi ; Vincent Schlageter ; Jean-Marc Vesin ; Steve Aellen ; Nicolas Peloponissios ; Aris D¡¯Ambrogio ; Paul Herman Wiesel ; Jean-Claude Givel ; Pavel Kucera and Nathalie Virag
• 关键词：Colon ; Electrical stimulation ; Implantable device ; Pig
• 刊名：Annals of Biomedical Engineering
• 出版年：2010
• 出版时间：July, 2010
• 年：2010
• 卷：38
• 期：7
• 页码：2398-2405
• 全文大小：571.4 KB

文摘

Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7–15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2–5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92 % of all stimulations. A cecal shortening of about 30 % and an average intraluminal pressure increase of 10.0 ¡À 6.0 mmHg were observed.