Computational modeling of the WHO grade II glioma dynamics: principles and applications to management paradigm

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• 作者：Emmanuel Mandonnet ; Johan Pallud ; Olivier Clatz ; Luc Taillandier ; Ender Konukoglu ; Hugues Duffau and Laurent Capelle
• 关键词：Glioma dynamics ; Biomathematical modeling ; Glioma surgery ; Low ; grade glioma
• 刊名：Neurosurgical Review
• 出版年：2008
• 出版时间：July, 2008
• 年：2008
• 卷：31
• 期：3
• 页码：263-269
• 全文大小：180.1 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurosurgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-2320

文摘

The advent of magnetic resonance imaging (MRI) has allowed the follow-up of tumor growth by precise volumetric measurements. Such information about tumor dynamics is, however, usually not fully integrated in the therapeutic management, and the assessment of tumor evolution is still limited to qualitative description. In parallel, computational models have been developed to simulate in silico tumor growth and treatment efficacy. Nevertheless, direct clinical interest of these models remains questionable, and there is a gap between scientific advances and clinical practice. In this paper, WHO grade II glioma will serve as a paradigmatic example to illustrate that computational models allow characterizing tumor dynamics from serial MRIs. The role of these dynamics for both therapeutic management and biological research will be discussed.