Impact of Vitamin A Supplementation on RAR Gene Expression in Multiple Sclerosis Patients

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• 作者：Sama Bitarafan (1)
  Mohammad Hossein Harirchian (2)
  Mohammad Ali Sahraian (3)
  Mohammad Keramatipour (4)
  Nahid Beladi Moghadam (5)
  Mansoureh Togha (6)
  Shahriar Nafissi (7)
  Fereydoun Siassi (8)
  Mohammad Reza Eshraghian (9)
  Niyaz Mohammadzadeh Honarvar (1)
  Hasti Ansar (1)
  Saeed Talebi (4)
  Ali Akbar Saboor-Yarghi (1)
  
• 关键词：Multiple sclerosis ; Retinoic acid receptor ; Retinyl palmitate ; Gene expression
• 刊名：Journal of Molecular Neuroscience
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：51
• 期：2
• 页码：478-484
• 全文大小：
• 作者单位：Sama Bitarafan (1)
  Mohammad Hossein Harirchian (2)
  Mohammad Ali Sahraian (3)
  Mohammad Keramatipour (4)
  Nahid Beladi Moghadam (5)
  Mansoureh Togha (6)
  Shahriar Nafissi (7)
  Fereydoun Siassi (8)
  Mohammad Reza Eshraghian (9)
  Niyaz Mohammadzadeh Honarvar (1)
  Hasti Ansar (1)
  Saeed Talebi (4)
  Ali Akbar Saboor-Yarghi (1)
  
  1. School of Nutritional Sciences and Dietetics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran
  3. Department of Neurology, Sina MS Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  8. Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran
  9. Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  
• ISSN：1559-1166

文摘

Vitamin A and its derivatives have been shown to modulate the immune system via retinoic acid receptor (RAR). This study explored the impact of retinyl palmitate supplementation on RAR subtype gene expression in peripheral blood mononuclear cells (PBMCs) in multiple sclerosis (MS) patients. The study designed as a double-blind randomized clinical trial in which relapsing remitting multiple sclerosis patients were evaluated. Both groups received one capsule 50,000IU vitamin D3 per 2weeks and one intramuscular injection interferon beta-1a per week. The intervention group received one 25,000IU retinyl palmitate capsule daily for 6months and the placebo group received one placebo capsule daily. The PBMCs were isolated from participants and the expression level changes of RAR-and RAR-genes were determined by real-time PCR. After supplementation, in the intervention group, the RAR-gene expression level was significantly decreased compared to the placebo group (p=0.03); however, the expression of RAR-gene did not significantly change (p=0.10). These results show that vitamin A supplementation can significantly downregulate the expression of RAR-gene in PBMCs of MS patients that suggest the presence of in vivo regulatory mechanisms for the action of vitamin A on the immune system.