The Effect of Vitamin A Supplementation on FoxP3 and TGF-β Gene Expression in Avonex-Treated Multiple Sclerosis Patients

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• 作者：Ali Akbar Saboor-Yaraghi ; Mohammad Hossein Harirchian…
• 关键词：TGF ; β ; FoxP3 ; Gene expression ; Vitamin A ; Multiple sclerosis
• 刊名：Journal of Molecular Neuroscience
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：56
• 期：3
• 页码：608-612
• 全文大小：176 KB
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• 作者单位：Ali Akbar Saboor-Yaraghi (1) (7)
  Mohammad Hossein Harirchian (2)
  Niyaz Mohammadzadeh Honarvar (1)
  Sama Bitarafan (2)
  Mina Abdolahi (1)
  Feridoun Siassi (3)
  Eisa Salehi (4)
  Mohammad Ali Sahraian (5)
  Mohammad Reza Eshraghian (6)
  Tina Roostaei (2)
  Fariba Koohdani (1)
  
  1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  7. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. Iranian Center of Neurological Research, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. Sina MS Research Center, Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran
  6. Department of Biostatistic, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  
• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Multiple sclerosis (MS) is an autoinflammatory condition of the central nervous system with impaired T helper (Th)17 and regulatory T cell (Treg) balance that is involved in disease immunopathogenesis. The vitamin A active metabolite, retinoic acid, can re-establish this imbalance through the modulation of gene expression of specific nuclear receptors including Forkhead box P3 (FoxP3). At present, few data exist on the impact of vitamin A supplementation on T cell balance. This study reports the results of a clinical trial, over a 6-month period, of 36 relapsing-remitting MS (RRMS) patients that received vitamin A (25,000?IU retinyl palmitate) or placebo (one capsule of placebo per day). Peripheral blood mononuclear cells were isolated from patients, and the expression of FoxP3 and transforming growth factor (TGF)-β gene expression was measured using real-time PCR at the beginning and end of the study. The results of this study showed that vitamin A upregulated TGF-β and FoxP3 gene expression. Therefore, vitamin A supplementation can be considered as a new approach in MS prevention and treatment.