MDCT findings of pancreatic metastases according to primary tumors

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• 作者：Tae Won Choi ; Se Hyung Kim ; Cheong-Il Shin ; Joon Koo Han…
• 关键词：Metastasis ; Pancreas ; Multidetector computed tomography
• 刊名：Abdominal Imaging
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：40
• 期：6
• 页码：1595-1607
• 全文大小：5,737 KB
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• 作者单位：Tae Won Choi (1)
  Se Hyung Kim (1)
  Cheong-Il Shin (1)
  Joon Koo Han (1)
  Byung Ihn Choi (1)
  
  1. Department of Radiology, Institute of Radiation Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Gastroenterology
  Hepatology
  
• 出版者：Springer New York
• ISSN：1432-0509

文摘

Purpose To describe the clinical and MDCT findings of metastatic pancreatic tumors (MPTs) from various primary malignancies and to determine whether there are characteristic imaging features of MPTs according to the various histologies of primary tumors. Materials and methods Thirty-six patients with pathologically proven MPTs who underwent MDCT were retrospectively enrolled. Mean survival and factors associated with prolonged survival were analyzed using multivariate Cox regression analysis. MDCT was analyzed for the location, number, margin, and pattern and degree of enhancements of MPTs and main pancreatic duct (MPD) dilatations. Significant differences in CT features among the various histologies of MPTs were determined using the χ 2 or Fisher’s exact test. Results The most common primary tumors metastasized to the pancreas were renal cell carcinomas (RCC) (n?=?17), gastric cancers (n?=?7), and colorectal cancers (n?=?5). Mean survival was significantly different between RCC (106.7?months) and non-RCC (25.1?months) metastases (P?<?0.001). A primary tumor of RCC was the only factor associated with prolonged survival (hazard ratio: 0.106, P?=?0.003). On MDCT, pancreatic metastases from RCC were frequently multifocal, located at the center of the pancreas, usually homogeneous and well-defined with early wash-in and persistent enhancement; non-RCC metastases tended to be solitary, located off-center (P?<?0.05), and appeared as heterogeneous, ill-defined nodules with persistent low attenuation (P?<?0.05). Conclusion Various non-RCC tumors as well as RCCs metastasize to the pancreas but a primary tumor of RCC is the only factor associated with prolonged survival. MDCT features of MPTs are significantly different between the RCC and non-RCC metastases, potentially aiding in their differentiation and selection of the most appropriate management options for these patients.