Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice

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• 作者：Claudia Cavelti-Weder ; Weida Li ; Adrian Zumsteg ; Marianne Stemann-Andersen…
• 关键词：Diabetes ; Exocrine to beta cell reprogramming ; Hyperglycaemia
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：59
• 期：3
• 页码：522-532
• 全文大小：7,594 KB
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• 作者单位：Claudia Cavelti-Weder (1)
  Weida Li (2) (3)
  Adrian Zumsteg (3)
  Marianne Stemann-Andersen (1)
  Yuemei Zhang (3)
  Takatsugu Yamada (1)
  Max Wang (3)
  Jiaqi Lu (3)
  Agnes Jermendy (1)
  Yong Mong Bee (1)
  Susan Bonner-Weir (1)
  Gordon C. Weir (1)
  Qiao Zhou (3)
  
  1. Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard University, Boston, MA, USA
  2. Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Life Sciences and Technology, Shanghai, The People’s Republic of China
  3. Department of Stem Cell and Regenerative Biology, Harvard University, Sherman Fairchild 258C, 7 Divinity Ave, Cambridge, MA, 02138, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Reprogramming of pancreatic exocrine to insulin-producing cells by viral delivery of the genes encoding transcription factors neurogenin-3 (Ngn3), pancreas/duodenum homeobox protein 1 (Pdx1) and MafA is an efficient method for reversing diabetes in murine models. The variables that modulate reprogramming success are currently ill-defined.