DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid
详细信息 查看全文
- 作者：Jun Shirakawa ; Tomoko Okuyama ; Mayu Kyohara…
- 关键词：Type 2 diabetes ; DPP ; 4 inhibitor ; Life span ; Insulin resistance ; Pancreatic β cell ; Adipose tissue
- 刊名：Diabetology and Metabolic Syndrome
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：8
- 期：1
- 全文大小：1,660 KB
- 刊物主题：Diabetes; Metabolic Diseases; Endocrinology;
- 出版者：BioMed Central
- ISSN：1758-5996
文摘
Background Diabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated that DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in β cell-specific glucokinase haploinsufficient mice fed a diet containing a combination of sucrose and linoleic acid (SL).