Fucoidan from Acaudina molpadioides protects pancreatic islet against cell apoptosis via inhibition of inflammation in type 2 diabetic mice

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• 作者：Jinhui Wang ; Shiwei Hu ; Jingfeng Wang ; Shijie Li…
• 关键词：fucoidan ; apoptosis ; inflammatory cytokine ; pancreatic islet ; Acaudina molpadioides
• 刊名：Food Science and Biotechnology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：25
• 期：1
• 页码：293-300
• 全文大小：684 KB
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• 作者单位：Jinhui Wang (1)
  Shiwei Hu (1) (2)
  Jingfeng Wang (2)
  Shijie Li (1)
  Wei Jiang (1) (2)
  
  1. Innovation Application Institute, Zhejiang Ocean University, Zhoushan, 316022, China
  2. College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

Inflammation induces pancreatic islet cell apoptosis. Effects of fucoidan from Acaudina molpadioides (Am-FUC) on inhibition of pancreatic islet cell apoptosis and inflammation in type 2 diabetic mice were investigated. Am-FUC repaired pancreatic islet cells, decreased serum C-reactive protein (CRP), macrophage inflammatory protein 1 (MIP-1), interleukin 1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) levels, and increased the IL-10 level. Am-FUC also reduced TNF-α, CRP, MIP-1, IL-1β, and IL-6 mRNA expressions, and increased IL-10 mRNA expression in epididymal adipose tissues. Am-FUC reduced Bid, Bax, cytochrome c, caspase 9, and caspase 3 mRNA expressions, and increased Bcl-2 and Bcl-xL mRNA expressions. Am-FUC down-regulated t-Bid, Bax, cytochrome c, and caspase 9 activities, cleaved caspase 3 proteins, and up-regulated Bcl-2 and Bcl-xL proteins. Thus, an Am-FUCblocked mitochondrial pathway was the suppression mechanism in pancreatic islet cell apoptosis via regulation of inflammatory cytokines providing dietary intervention in type 2 diabetes and inflammation-induced pancreatic islet apoptosis.