Mitochondrial mutations and metabolic adaptation in pancreatic cancer

详细信息    查看全文

• 作者：Rae-Anne Hardie ; Ellen van Dam ; Mark Cowley ; Ting-Li Han…
• 关键词：Pancreas ; Mitochondria ; Metabolomics ; Glutamine ; Lipid ; Genome
• 刊名：Cancer & Metabolism
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：5
• 期：1
• 全文大小：1571KB
• 刊物主题：Cancer Research; Oncology; Metabolomics; Metabolic Diseases; Imaging / Radiology; Cell Biology;
• 出版者：BioMed Central
• ISSN：2049-3002
• 卷排序：5

文摘

BackgroundPancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as pancreatic cancer, which are driven by genetic alterations that are not tractable drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been observed in various tumors types, understanding of metabolic genotype-phenotype relationships is limited.