Connexins and pannexins in the immune system and lymphatic organs

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• 作者：Aaron M. Glass ; Elizabeth G. Snyder…
• 关键词：Connexin ; Pannexin ; Immunity ; T ; cell ; Macrophage ; Lymphatic
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：72
• 期：15
• 页码：2899-2910
• 全文大小：465 KB
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• 作者单位：Aaron M. Glass (1)
  Elizabeth G. Snyder (1)
  Steven M. Taffet (1)
  
  1. Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY, 13210, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Connexin43 and pannexin1 are found in immune cells. While gap junctional communication has been demonstrated between immune cells, hemichannels have been implicated in many cellular functions. Among the functions involved as being connexin dependent and pannexin dependent are cell migration, phagocytosis, antigen presentation, T-cell reactivity and B-cell responses. Surprisingly, many of these connexin-related and pannexin-related functions are not recapitulated in in vivo models. This is leading to a reevaluation of the role of these proteins in immune function.