Connexin and pannexin channels in cancer

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• 作者：Jean X. Jiang ; Silvia Penuela
• 刊名：BMC Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1-supp
• 全文大小：522 KB
• 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2121
• 卷排序：17

文摘

Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and their effect in cellular communication, can either enhance or suppress tumorigenesis and metastasis. In this review, we will highlight the latest reports on the role of the well characterized connexin family and its ability to form gap junctions and hemichannels in cancer. We will also introduce the more recently discovered family of pannexin channels and our current knowledge about their involvement in cancer progression.