Multicentric Reticulohistiocytosis: a Rare Yet Challenging Disease

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• 作者：Arshia D. Islam (1)
  Stanley M. Naguwa (1)
  Gurtej S. Cheema (1)
  John C. Hunter (2)
  M. Eric Gershwin (1)
  
• 关键词：Papulonodular cutaneous lesions ; Symmetric erosive arthritis ; Histiocytosis ; Multinucleated giant cells ; Ground glass eosinophilic cytoplasm
• 刊名：Clinical Reviews in Allergy & Immunology
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：45
• 期：2
• 页码：281-289
• 全文大小：
• 作者单位：Arshia D. Islam (1)
  Stanley M. Naguwa (1)
  Gurtej S. Cheema (1)
  John C. Hunter (2)
  M. Eric Gershwin (1)
  
  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA, 95616, USA
  2. Department of Radiology, University of California at Davis, Sacramento Medical Center, Sacramento, CA, 95817, USA
  
• ISSN：1559-0267

文摘

Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.