Structures affecting recovery of macular function in patients with age-related macular degeneration after intravitreal ranibizumab

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• 作者：Tomoharu Nishimura ; Shigeki Machida…
• 关键词：Age ; related macular degeneration ; Ranibizumab ; Focal macular ERG ; ERG ; SD ; OCT
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：253
• 期：8
• 页码：1201-1209
• 全文大小：1,012 KB
• 参考文献：1.Brown DM, Kaiser PK, Michels M, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S, ANCHOR Study Group (2006) Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355:1432-444PubMed View Article
  2.Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, MARINA study group (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419-431PubMed View Article
  3.Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Lanchulev T, ANCHOR study group (2009) Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 116:57-5PubMed View Article
  4.Mitchell P, Korobelnik J-F, Lazetta P, Holtz FG, Prünte C, Schmidt-Erfurth U, Tano Y, Wolf S (2010) Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials. Br J Ophthalmol 94:2-3PubMed View Article
  5.Lalwani GA, Rosenfeld PJ, Fung AE, Dubovy SR, Michels S, Feuer W, Davis JL, Flynn HW Jr, Esquiabro M (2009) A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO study. Am J Ophthalmol 148:43-8PubMed View Article
  6.Ritter M, Bolz M, Sacu S, Deák GG, Kiss C, Prünte C, Schmidt-Erfurth U (2010) Effect of intravitreal ranibizumab in avascular pigement epithelial detachment. Eye (Lond) 24:962-68View Article
  7.Cho HJ, Kim CG, Yoo SJ, Cho SW, Lee DW, Kim JW, Lee JH (2013) Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration treated with ranibizumab. Am J Ophthalmol 155:118-26PubMed View Article
  8.Munk MR, Kiss C, Huf W, Sulzbacher F, Roberts P, Mittermüller TJ, Sacu S, Simader C, Schmidt-Erfurth U (2013) One year follow-up of functional recovery in neovascular AMD during monthly anti-VEGF treatment. Am J Ophthalmol 156:633-43PubMed View Article
  9.Ogino K, Tsujikawa A, Yamashiro K, Ooto S, Oishi A, Nakata I, Miyake M, Takahashi A, Ellabban AA, Yoshimura N (2014) Multimodal evaluation of macular function in age-related macular degeneration. Jpn J Ophthalmol 58:155-65PubMed View Article
  10.Nishihara H, Kondo M, Ishikawa K, Sugita T, Pia CH, Nakamura Y, Terasaki H (2008) Focal macular electroretinograms in eyes with wet-type age-related macular degeneration. Invest Ophthalmol Vis Sci 49:3121-125PubMed View Article
  11.Iwata E, Ueno S, Ishikawa K, Ito Y, Uetani R, PIao CH, Kondo M, Terasaki H (2012) Focal macular electroretinograms after intravitreal injections of bevacizumab for age-related macular degeneration. Invest Ophthamol Vis Sci 53:4185-190View Article
  12.Nishimura T, Machida S, Harada T, Kurosaka D (2012) Retinal ganglion cell function after repeated intravitreal injections of renibizumab in patients with age-related macular degeneration. Clin Ophthalmol 6:1073-082PubMed Central PubMed
  13.Ogino K, Tsujikawa A, Yamashiro K, Ooto S, Oishi A, Nakata I, Miyake M, Yoshimura N (2013) Intravitreal injection of ranibizumab for recovery of macular function in eyes with subfoveal polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 54:3771-779PubMed View Article
  14.Moschos MM, Brouzas D, Apostolopoulos M, Koutsandrea C, Loukianou E, Moschos M (2007) Intravitreal use of bevacizumab (Avastin) for choroidal neovascularization due to ARMD: a preliminary multifocal-ERG and OCT study. Multifocal-ERG after use of bevacizumab in ARMD. Doc Ophthalmol 114:37-4PubMed View Article
  15.Campa C, Hagan R, Sahni JN, Brown MC, Heimann H, Harding SP (2011) Erarly multifocal electoretinogram findings during intravitreal ranibizumab treatment for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 52:3446-451PubMed View Article
  16.Miyake Y, Yanagida K, Kondo K, Ota I (1981) Subjective scotometry and recording of local electroretinogram and visual evoked response. System with television monitor of the fundus. Jpn J Ophthalmol 25:439-48
  17.Miyake Y (1988) Studies on local macular ERG. Acta Soc Ophthalmol Jpn 92:1419-449
  18.Machida S, Toba Y, Ohtaki A, Gotoh Y, Kaneko M, Kurosaka D (2008) Photopic negative response of focal electroretinogram in glaucomatous eyes. Invest Ophthalmol Vis Sci 49:5636-644PubMed View Article
  19.Tamada K, Machida S, Oikawa T, Miyamoto H, Nishimura T, Kurosaka D (2010) Correlation between photopic negative response of focal electroretinograms and local loss of retinal neurons in glaucoma. Curr Eye Res 35:155-64PubMed View Article
  20.Kizawa J, Machida S, Kobayashi T, Gotoh Y, Kurosaka D (2006) Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy. Jpn J Ophthalmol 50:367-73PubMed View Article
  21.Bush RA, Sieving PA (1994) A proximal retinal component in the primate photopic ERG a-wave. Invest Ophthalmol Vis Sci 35:635-45PubMed
  22.Kondo M, Ueno S, Piao CH, Miy
• 作者单位：Tomoharu Nishimura (1)
  Shigeki Machida (1) (2)
  Kouhei Hashizume (1)
  Daijiro Kurosaka (1)
  
  1. Department of Ophthalmology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan
  2. Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose To determine the retinal structures affecting the recovery of macular function in patients with exudative age-related macular degeneration (AMD) treated with intravitreal ranibizumab (IVR). Method Thirty eyes of 30 patients with exudative AMD who were treated with IVR at monthly intervals for 3?months were studied. Focal macular electroretinograms (fmERGs) and spectral-domain optical coherence tomography (SD-OCT) were performed before and 3?months after beginning the IVR injections. The fmERGs were elicited by a 15° white stimulus spot centered on the fovea. The thickness of different retinal layers, presence of a serous retinal detachment (SRD), and presence of a pigment epithelial detachment (PED) at the fovea was determined in the SD-OCT images. Measurements were made of the inner, middle, and outer layers of the retina and also of the SRD and PED in the horizontal and vertical meridians at 1.2?mm from the fovea (parafoveal regions). The significance of the correlations between these structural parameters and the a-wave amplitude of the fmERG was determined. Results There was no significant correlation between the structural parameters of the fovea and the a-wave amplitude. In the parafoveal regions, the thickness of the outer retinal layer was significantly correlated with an increase of the a-wave amplitude (R--.56, P--.001). In addition, the SRD thickness was negatively and significantly correlated with the a-wave amplitude (R-??0.54, P--.002). The change in the parafoveal SRD thickness after IVRs was the only independent determinant of recovery of the a-wave amplitude after the treatments (P-lt;-.05). Conclusions The macular function measured by the fmERGs was determined by the parafoveal outer layer and SRD thickness in patients with exudative AMD. Of these, changes in the SRD thickness by IVRs most strongly affected the recovery of macular function.