Demyelinating optic neuritis: Optical coherence tomography and multifocal electroretinography data correlation
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- 作者：V. V. Neroev ; E. K. Eliseeva ; M. V. Zueva ; V. S. Lysenko…
- 关键词：optic neuritis ; multiple sclerosis ; retina ; optical coherence tomography ; multifocal electroretinography
- 刊名：Human Physiology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：42
- 期：8
- 页码：879-884
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences, general; Human Physiology; Biomedicine, general;
- 出版者：Pleiades Publishing
- ISSN：1608-3164
- 卷排序：42
文摘
Optical coherence tomography (OCT) and multifocal electroretinography (mfERG) data using 61 hexagons are presented in three groups of patients: (1) with multiple sclerosis (MS) and optic neuritis (ON) (14 patients), (2) with ON of unknown etiology (19 patients), and (3) with ON of infectious etiology (12 patients). In the patients with MS, the correlation of the latency of the P1 component of mfERG in the parafovea with the retinal thickness in the central zone in all the quadrants of the fundus (except for the superior one) and with the total macular volume has been revealed, which makes it possible to use this mfERG parameter as a marker of MS progression. The results of the current study have demonstrated that the density ratio R1/Rx may be used as an additional marker of the acute stage in diagnostic process. Patients with ON of infectious etiology were characterized by a decrease in the retinal thickness in the parafoveal zone of the temporal and inferior quadrants and reduction in the density and amplitude of P1 in all the rings.