Preliminary study on serum paraoxonase-1 status and chemokine (C-C motif) ligand 2 in hospitalized elderly patients with catheter-associated asymptomatic bacteriuria

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• 作者：S. Iftimie ; A. García-Heredia ; I. Pujol…
• 刊名：European Journal of Clinical Microbiology & Infectious Diseases
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：35
• 期：9
• 页码：1417-1424
• 全文大小：384 KB
• 参考文献：1.High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, Richards C, Yoshikawa TT (2009) Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the infectious diseases society of America. Clin Infect Dis 48(2):149–171CrossRef PubMed
  2.Nicolle LE (2014) Catheter-related urinary tract infection: practical management in the elderly. Drugs Aging 31(1):1–10CrossRef PubMed
  3.Trautner BW (2010) Management of catheter-associated urinary tract infection. Curr Opin Infect Dis 23(1):76–82CrossRef PubMed PubMedCentral
  4.Theodorou VP, Papaioannou VE, Tripsianis GA, Panopoulou MK, Christophoridis EK, Kouliatsis GA, Gioka TM, Maltezos ES, Ktenidou-Kartali SI, Pneumatikos IA (2012) Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study. BMC Infect Dis 12:247CrossRef PubMed PubMedCentral
  5.Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, Infectious Diseases Society of America; American Society of Nephrology; American Geriatric Society (2005) Infectious Diseases Society of America Guidelines for the diagnosis and treatment of symptomatic bacteriuria in adults. Clin Infect Dis 40(5):643–654CrossRef PubMed
  6.Zhanel GG, Harding GK, Guay DR (1990) Asymptomatic bacteriuria. Which patients should be treated. Arch Intern Med 150(7):1389–1396CrossRef PubMed
  7.Nicolle LE (2000) Asymptomatic bacteriuria in institutionalized elderly people; evidence and practice. CMAJ 163(3):285–286PubMed PubMedCentral
  8.Henriquez-Camacho C, Losa J (2014) Biomarkers for sepsis. Biomed Res Int 2014:547818CrossRef PubMed PubMedCentral
  9.Iftimie S, García-Heredia A, Pujol I, Ballester F, Fort-Gallifa I, Simó JM, Joven J, Castro A, Camps J (2015) A preliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter. Clin Biochem 49(6):449–457. doi:10.​1016/​j.​clinbiochem.​2015.​11.​006
  10.Camps J, Marsillach J, Joven J (2009) The paraoxonases: role in human diseases and methodological difficulties in measurement. Crit Rev Clin Lab Sci 46(2):83–106CrossRef PubMed
  11.Mete R, Oran M, Alpsoy S, Gunes H, Tulubas F, Turan C, Topcu B, Aydin M, Yildirim O (2013) Carotid intima-media thickness and serum paraoxonase-1 activity in patients with Helicobacter pylori. Eur Rev Med Pharmacol Sci 17(21):2884–2889PubMed
  12.Parra S, Marsillach J, Aragonés G, Beltrán R, Montero M, Coll B, Mackness B, Mackness M, Alonso-Villaverde C, Joven J, Camps J (2010) Paraoxonase-1 gene haplotypes are associated with metabolic disturbances, atherosclerosis, and immunologic outcome in HIV-infected patients. J Infect Dis 201(4):627–634CrossRef PubMed
  13.Richter RJ, Jarvik GP, Furlong CE (2010) Paraoxonase 1 status as a risk factor for disease or exposure. Adv Exp Med Biol 660:29–35CrossRef PubMed PubMedCentral
  14.McCabe WR, Jackson GG (1962) Gram-negative bacteremia. I. Etiology and ecology. Arch Intern Med 110:847–864CrossRef
  15.Berkman LF, Leo-Summers L, Horwitz RI (1992) Emotional support and survival after myocardial infarction. A prospective, population-based study of the elderly. Ann Intern Med 117(12):1003–1009CrossRef PubMed
  16.Ferré N, Camps J, Fernández-Ballart J, Arija V, Murphy MM, Ceruelo S, Biarnés E, Vilella E, Tous M, Joven J (2003) Regulation of serum paraoxonase activity by genetic, nutritional, and lifestyle factors in the general population. Clin Chem 49(9):1491–1497CrossRef PubMed
  17.Marsillach J, Aragonès G, Beltrán R, Caballeria J, Pedro-Botet J, Morcillo-Suárez C, Navarro A, Joven J, Camps J (2009) The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment. Clin Biochem 42(1–2):91–98CrossRef PubMed
  18.Martinelli N, Garcia-Heredia A, Roca H, Aranda N, Arija V, Mackness B, Busti F, Aragonès G, Pedro-Botet J, Pedica F, Cataldo I, Marsillach J, Joven J, Girelli D, Camps J (2013) Paraoxonase-1 status in patients with hereditary hemochromatosis. J Lipid Res 54(5):1484–1492CrossRef PubMed PubMedCentral
  19.Andreu A, Cacho J, Coira A, Lepe JA (2011) Diagnóstico microbiológico de las infecciones del tracto urinario. Enferm Infecc Microbiol Clin 29:52–57CrossRef PubMed
  20.Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39(4):561–577PubMed
  21.Aviram M, Rosenblat M, Billecke S, Erogul J, Sorenson R, Bisgaier CL, Newton RS, La Du B (1999) Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Rad Biol Med 26(7–8):892–904CrossRef PubMed
  22.Camps J, Mackness M, Mackness B, Marsillach J, Joven J (2010) Serum paraoxonase-1 activity and genetic polymorphisms: common errors in measurement and interpretation of results. Clin Chem Lab Med 48(6):893–894CrossRef PubMed
  23.Camps J, Rodríguez-Gallego E, García-Heredia A, Triguero I, Riera-Borrull M, Hernández-Aguilera A, Luciano-Mateo F, Fernández-Arroyo S, Joven J (2014) Paraoxonases and chemokine (C-C motif) ligand-2 in noncommunicable diseases. Adv Clin Chem 63:247–308CrossRef PubMed
  24.Charo IF, Taubman MB (2004) Chemokines in the pathogenesis of vascular disease. Circ Res 95(9):858–866CrossRef PubMed
  25.Mackness B, Hine D, Liu Y, Mastorikou M, Mackness M (2004) Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells. Biochem Biophys Res Commun 318(3):680–683CrossRef PubMed
  26.Rodríguez-Sanabria F, Rull A, Beltrán-Debón R, Aragonès G, Camps J, Mackness B, Mackness M, Joven J (2010) Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisations suggest a systemic and coordinated role. J Mol Histol 41(6):379–386CrossRef PubMed
  27.Rull A, Camps J, Alonso-Villaverde C, Joven J (2010) Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism. Mediators Inflamm
  28.Petrkova J, Szotkowska J, Hermanova Z, Lukl J, Petrek M (2004) Monocyte chemoattractant protein-1 in patients with peripheral arterial disease. Mediat Inflamm 13(1):39–43CrossRef
  29.Sans T, Rull A, Luna J, Mackness B, Mackness M, Joven J, Ibañez M, Pariente R, Rodriguez M, Ortin X, Masdeu G, Camps J (2012) Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report. Clin Chem Lab Med 50(8):1409–1415CrossRef PubMed
  30.Ramanathan R, Duane TM (2014) Urinary tract infections in surgical patients. Surg Clin Borth Am 94(6):1351–1368CrossRef
  31.Becknell B, Schober M, Korbel L, Spencer JD (2015) The diagnosis, evaluation and treatment of acute and recurrent pediatric urinary tract infections. Expert Rev Anti Infect Ther 13(1):81–90CrossRef PubMed
  32.Khasriya R, Khan S, Lunawat R, Bishara S, Bignall J, Malone-Lee M, Ishii H, O’Connor D, Kelsey M, Malone-Lee J (2010) The inadequacy of urinary dipstick and microscopy as surrogate markers of urinary tract infection in urological outpatients with lower urinary tract symptoms without acute frequency and dysuria. J Urol 183(5):1843–1847CrossRef PubMed
  33.Wang H, Yin F, Shen DX, Zhang YJ, Luo YP, Liu CJ, Wang KF, Zhou G, Ye LY, Chen G, Wang XN (2013) Predictive value of procalcitonin for excluding bloodstream infection: results of a retrospective study and utility of a rapid, quantitative test for procalcitonin. J Int Med Res 41(5):1671–1681CrossRef PubMed
  34.Feneley RC, Kunin CM, Stickler DJ (2012) An indwelling urinary catheter for the 21st century. BJU Int 109(12):1746–1749CrossRef PubMed
  35.Camps J, Pujol I, Ballester F, Joven J, Simó JM (2011) Paraoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteria. Antimicrob Agents Chemother 55(4):1325–1331CrossRef PubMed PubMedCentral
  36.Liu YC, Chan KG, Chang CY (2015) Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: Messengers or traitors. Front Microbiol 6:1226PubMed PubMedCentral
  37.Ozer EA, Pezzulo A, Shih DM, Chun C, Furlong C, Lusis AJ, Greenberg EP, Zabner J (2005) Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum sensing. FEMS Microbiol Lett 253(1):29–37CrossRef PubMed
  38.Schweikert EM, Amort J, Wilgenbus P, Förstermann U, Teiber JF, Horke S (2012) Paraoxonases-2 and −3 are important defense enzymes against Pseudomonas aeruginosa virulence factors due to their anti-oxidative and anti-inflammatory properties. J Lipids 2012:352857CrossRef PubMed PubMedCentral
  
• 作者单位：S. Iftimie (1)
  A. García-Heredia (2)
  I. Pujol (3)
  F. Ballester (3)
  I. Fort-Gallifa (2) (3)
  J. M. Simó (3)
  J. Joven (1)
  J. Camps (1)
  A. Castro (2)
  
  1. Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Unitat de Recerca Biomèdica, C. Sant Joan, s/n, 43201, Reus, Catalonia, Spain
  2. Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C. Sant Joan, s/n, 43201, Reus, Catalonia, Spain
  3. Laboratori de Referència Sud, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Comerç 42, 43204, Reus, Catalonia, Spain
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-4373
• 卷排序：35

文摘

Urinary tract infections (UTI) are common among elderly patients in residential care facilities, as well as in the hospital setting. Identifying new biochemical markers of UTI is an active line of research since UTI management is resource intensive. Paraoxonase-1 (PON1) forms part of the patient’s immune system, the response-to-injury and inflammation. Our study sought to evaluate alterations in inflammation-related paraoxonase-1 (PON1) and chemokine (C-C motif) ligand 2 (CCL2) in patients with an indwelling catheter to assess their potential usefulness as biomarkers of infection. Patients (n = 142) who had had the urinary catheter removed and 100 healthy volunteers were recruited. In all participants we measured serum PON1 activity, PON1 concentration, CCL2, procalcitonin and C-reactive protein (CRP). Results indicated that patients had higher CCL2, CRP and procalcitonin concentrations than the control group, and lower paraoxonase activity. There were no significant differences in PON1 concentrations. When comparing the diagnostic accuracy of CRP, procalcitonin, CCL2 and the PON1-related variables in discriminating between patients with and those without UTI, we found a considerable degree of overlap between groups, i.e., a low diagnostic accuracy. However, there were significant inverse logarithmic correlations between serum paraoxonase activity and the number of days the urinary catheter had been in situ. Our results suggest that measurement of these biochemical variables may be useful in investigating complications of long-term use of these devices and help to improve the economic and clinical investment required in the management of the often-associated infection. An erratum to this article can be found at http://​dx.​doi.​org/​10.​1007/​s10096-016-2718-5.