Lignan and flavonoids from the stems of Zea mays and their anti-inflammatory and neuroprotective activities

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• 作者：Ye-Jin Jung ; Ji-Hae Park ; Jin-Gyeong Cho ; Kyeong-Hwa Seo…
• 关键词：Anti ; inflammation ; Cornstalk ; HT22 ; Neuroprotection ; RAW 264.7 ; Tetrahydro ; 4 ; 6 ; bis(4 ; hydroxy ; 3 ; methoxyphenyl) ; 1H ; 3H ; furo[3 ; 4 ; c]furan ; 1 ; one ; Zea mays
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：38
• 期：2
• 页码：178-185
• 全文大小：293 KB
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• 作者单位：Ye-Jin Jung (1)
  Ji-Hae Park (1)
  Jin-Gyeong Cho (1)
  Kyeong-Hwa Seo (1)
  Dong-Sung Lee (2)
  Youn-Chul Kim (2)
  Hee-Cheol Kang (3)
  Myoung-Chong Song (4)
  Nam-In Baek (1)
  
  1. Graduate School of Biotechnology and Oriental Medicinal Materials and Processing, Kyung Hee University, Yongin, 446-701, Republic of Korea
  2. College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea
  3. R&D Center, GFC Co., Ltd, Suwon, 443-813, Republic of Korea
  4. Intelligent Synthetic Biology Center, KAIST, Daejeon, 305-701, Republic of Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

The stems of Zea mays L., otherwise known as cornstalks, were extracted with 80?% aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, a new lignan along with three known flavonoids, tricin (1), salcolin A (2), and salcolin B (3), were isolated. The chemical structure of the lignan was determined to be tetrahydro-4,6-bis(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-one (4) through spectroscopic data analyses including NMR, MS, and IR. All compounds were isolated for the first time from this plant. The isolated compounds were evaluated for their inhibitory activity against NO production in Lipopolysaccharide-induced RAW 264.7 cells and their protective activity in glutamate-induced cell death in HT22 cells. The compounds 1, 2 and 4 showed anti-inflammatory effects with IC50 values of 2.63, 14.65, and 18.91?μM, respectively, as well as neuroprotective effects with EC50 values of 25.14, 47.44, and >80?μM, respectively.