Associations between CYP2A6 polymorphisms and outcomes of adjuvant S-1 chemotherapy in patients with curatively resected gastric cancer

详细信息    查看全文

• 作者：Jae Ho Jeong ; Sook Ryun Park ; Yongchel Ahn ; Min-Hee Ryu ; Baek-Yeol Ryoo…
• 关键词：CYP2A6 polymorphisms ; Gastric cancer ; S ; 1
• 刊名：Gastric Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：146-155
• 全文大小：607KB
• 刊物类别：Medicine
• 刊物主题：Surgical Oncology; Oncology; Abdominal Surgery; Gastroenterology; Cancer Research;
• 出版者：Springer Japan
• ISSN：1436-3305
• 卷排序：20

文摘

BackgroundOral fluoropyrimidine S-1 contains tegafur, which is metabolized to 5-fluorouracil by cytochrome P450 2A6 (CYP2A6). We here examined associations between CYP2A6 polymorphisms and treatment outcomes of adjuvant S-1 in gastric cancer patients.