Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis
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- 作者：Céline El Baou ; Rachael L. Di Santostefano…
- 关键词：Inhaled corticosteroids ; Particle size ; Asthma ; Systematic review ; Meta ; analysis
- 刊名：BMC Pulmonary Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：2427KB
- 刊物主题：Pneumology/Respiratory System; Internal Medicine; Intensive / Critical Care Medicine;
- 出版者：BioMed Central
- ISSN：1471-2466
- 卷排序：17
文摘
BackgroundInhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this may impact patient outcomes. This structured literature review and meta-analysis compared the effect of small and standard particle size ICS on lung function, symptoms, rescue use (when available) and safety in patients with asthma as assessed in head-to-head randomized controlled trials (RCTs).