The mechanistic role of epigenetic in multiple myeloma

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• 作者：Saeideh Hajizamani ; Neda Golchin ; Mohammad Shahjahani…
• 关键词：Multiple myeloma ; Epigenetic modifications ; Cell cycle ; Apoptosis ; DNA repair system ; CD markers ; Signaling pathway ; miRNA
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：6
• 页码：1279-1288
• 全文大小：534 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X
• 卷排序：25

文摘

Multiple myeloma (MM) is a B cell malignancy characterized by accumulation of malignant plasma cells in the bone marrow. Pathogenesis of MM involves a complex pattern of structural and numerical chromosomal aberrations. In addition, epigenetic changes such as DNA methylation and histone modifications may play a role in this disease by affecting the expression of different genes. This article reviews recent findings on the role of epigenetic alterations in MM pathogenesis, which affect the expression of cell cycle regulatory molecules, apoptosis, DNA repair system, CD markers, cell signaling pathways as well as tumor suppressor miRNAs. Given these results, it can be stated that these epigenetic changes play an important role in the initiation and progression of MM. Therefore, understanding the impact of epigenetics in MM pathogenesis in each stage of disease progression can help develop therapeutic targets to increase survival and reduce drug resistance.