In Vitro Antiviral Activity of Germacrone Against Porcine Reproductive and Respiratory Syndrome Virus

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• 作者：Jiaping Feng ; Xiaolei Bai ; Tiantian Cui ; Han Zhou ; Yao Chen…
• 刊名：Current Microbiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：73
• 期：3
• 页码：317-323
• 全文大小：639 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  
• 出版者：Springer New York
• ISSN：1432-0991
• 卷排序：73

文摘

Porcine reproductive and respiratory syndrome (PRRS) is one of the most serious diseases affecting the swine industry worldwide; however, there is no efficient control strategies against PRRSV at present. Therefore, development of new antiviral treatment strategies is urgently needed. As reported, germacrone can efficiently impair influenza virus replication. In this study, we exploited whether germacrone has the potential to inhibit PRRSV infection. Our results showed that the germacrone significantly inhibited replication of PRRSV in vitro and repressed the synthesis of viral RNA and protein. However, it did not block PRRSV binding and entry. Further studies confirmed that germacrone impaired PRRSV replication at an early stage, and inhibited infection of both classic and highly pathogenic type II PRRSV strains. Collectively, our findings imply that the germacrone has the potential to be used as an anti-PRRSV drug.Jiaping Feng, Xiaolei Bai and Tiantian Cui contributed equally to this work.