The therapeutic applications of antimicrobial peptides (AMPs): a patent review

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• 作者：Hee-Kyoung Kang ; Cheolmin Kim ; Chang Ho Seo ; Yoonkyung Park
• 关键词：antimicrobial peptide ; therapies ; drug candidate ; pathogenic bacteria
• 刊名：Journal of Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：55
• 期：1
• 页码：1-12
• 全文大小：
• 刊物主题：Microbiology;
• 出版者：The Microbiological Society of Korea
• ISSN：1976-3794
• 卷排序：55

文摘

Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.