INGs are potential drug targets for cancer

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• 作者：Runyun Zhang ; Jianhua Jin ; Juanjuan Shi…
• 关键词：INGs ; Tumor suppressors ; Cancer therapy ; Cell signaling
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：143
• 期：2
• 页码：189-197
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

PurposeThe inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer cell sensitivity for chemotherapy and radiotherapy, while clinical observations show that INGs are frequently lost in some types of cancers. The aim of the study was to summarize the recent progress regarding INGs regulating tumor progression.