Safety and effectiveness of a Patient Blood Management (PBM) program in surgical patients - the study design for a multi-centre prospective epidemiologic non-inferiority trial

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• 作者：Patrick Meybohm (1)
  Dania Patricia Fischer (1)
  Christof Geisen (3)
  Markus Matthias M眉ller (3)
  Christian Friedrich Weber (1)
  Eva Herrmann (2)
  Bj枚rn Steffen (4)
  Erhard Seifried (3)
  Kai Zacharowski (1)
  the German PBM Study Core Group
  
  1. Department of Anaesthesiology ; Intensive Care Medicine and Pain Therapy ; University Hospital Frankfurt ; Theodor-Stern-Kai 7 ; 60590 ; Frankfurt am Main ; Germany
  3. German Red Cross Blood Transfusion Service Baden-Wuerttemberg 鈥?Hessen ; Institute of Transfusion Medicine and Immunohematology ; Sandhofstrasse 1 ; Frankfurt am Main ; Germany
  2. Institute of Biostatistics and Mathematical Modelling ; University Hospital Frankfurt ; Theodor-Stern-Kai 7 ; 60590 ; Frankfurt am Main ; Germany
  4. Department of Haematooncology ; University Hospital Frankfurt ; Frankfurt am Main ; Germany
  
• 关键词：Patient Blood Management ; Red Blood Cell Transfusion Practice ; Patient Safety ; Anaemia ; Clinical Outcome ; Perioperative Care
• 刊名：BMC Health Services Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：993 KB
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  2. Koch, CG, Li, L, Sun, Z, Hixson, ED, Tang, A, Phillips, SC, Blackstone, EH, Henderson, JM (2013) Hospital-acquired anemia: Prevalence, outcomes, and healthcare implications. J Hosp Med 8: pp. 506-512 CrossRef
  3. Marik, PE, Corwin, HL (2008) Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 36: pp. 2667-2674 CrossRef
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  11. Shander, A, Aken, H, Colomina, MJ, Gombotz, H, Hofmann, A, Krauspe, R, Lasocki, S, Richards, T, Slappendel, R, Spahn, DR (2012) Patient blood management in Europe. Br J Anaesth 109: pp. 55-68 CrossRef
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  15. Acheson, AG, Brookes, MJ, Spahn, DR (2012) Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis. Ann Surg 256: pp. 235-244 CrossRef
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• 刊物主题：Public Health; Health Administration; Health Informatics; Nursing Management/Nursing Research;
• 出版者：BioMed Central
• ISSN：1472-6963

文摘

Background Preoperative and hospital-acquired anaemia is common among surgical patients. It is associated with an increased risk of morbidity and mortality and a strong risk factor for allogeneic blood transfusions with their own inherent risks. Patient Blood Management (PBM) concepts aim to increase and preserve autologous erythrocyte volume and to optimise haemotherapy. They thus have great potential to benefit patients. Methods/Design This prospective, multi-centre clinical trial tests the hypothesis that PBM programs are safe and effective in the care of adult surgical patients. Primary outcome is a composite endpoint of adverse events and in-hospital mortality. Discussion This trial will determine whether the implementation of a PBM program is safe and effective in terms of clinical outcome compared to a pre-implementation cohort. This trial is registered at www.clinicaltrials.gov (NCT01820949).