Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus
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- 作者：Kelvin K. W. To ; Candy C. Y. Lau ; Patrick C. Y. Woo ; Susanna K. P. Lau…
- 关键词：Avian influenza virus ; H7N9 ; Human ; Chicken ; Cytokine ; Chemokine ; Interferon ; Viral load ; Interferon lambda 1 ; IL ; 8
- 刊名：Virology Journal
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：835 KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
文摘
Background Avian influenza virus H7N9 has jumped species barrier, causing sporadic human infections since 2013. We have previously isolated an H7N9 virus from a patient, and an H7N9 virus from a chicken in a live poultry market where the patient visited during the incubation period. These two viruses were genetically highly similar. This study sought to use a human bronchial epithelial cell line model to infer the virulence of these H7N9 viruses in humans.