Association between malaria control and paediatric blood transfusions in rural Zambia: an interrupted time-series analysis

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• 作者：Alison B Comfort (1)
  Janneke H van Dijk (2)
  Sungano Mharakurwa (3)
  Kathryn Stillman (1)
  Benjamin Johns (1)
  Payal Hathi (1)
  Sonali Korde (4)
  Allen S Craig (5) (6)
  Nancy Nachbar (1)
  Yann Derriennic (1)
  Rose Gabert (1) (8)
  Philip E Thuma (7)
  
  1. International Health Division ; Abt Associates ; Cambridge ; MA ; USA
  2. Clinical Research Department ; Macha Research Trust ; Choma ; Zambia
  3. Johns Hopkins Malaria Research Institute ; Malaria Research Department ; Macha Research Trust ; Choma ; Zambia
  4. President鈥檚 Malaria Initiative ; Bureau of Global Health ; USAID ; Washington District of Columbia ; Washington ; DC ; USA
  5. President鈥檚 Malaria Initiative ; Division of Parasitic Diseases and Malaria ; Center for Global Health ; Centers for Disease Control and Prevention ; Lusaka ; Zambia
  6. Global Immunization Division ; Center for Global Health ; Centers for Disease Control and Prevention ; Atlanta ; GA ; USA
  8. The Institute for Health Metrics and Evaluation ; University of Washington ; Seattle ; WA ; USA
  7. Macha Research Trust ; Choma ; Zambia
  
• 关键词：Malaria control ; Blood transfusion ; Severe malarial anaemia ; Paediatric hospital admissions ; Zambia ; Sub ; Saharan Africa ; Time series
• 刊名：Malaria Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：1,147 KB
• 参考文献：World Malaria Report 2013. World Health Organization, Geneva
  1. Jamison, DT, Feachem, RG, Makgoba, MW, Bos, ER, Baingana, FK, Hofman, KJ, Rogo, KO (2006) Disease and Mortality in Sub-Saharan Africa. The International Bank for Reconstruction and Development/The World Bank, Washington, DC
  Guidelines for the Treatment of Malaria. World Health Organization, Geneva, Switzerland
  2. Obonyo, CO, Vulule, J, Akhwale, WS, Grobbee, DE (2007) In-hospital morbidity and mortality due to severe malarial anaemia in Western Kenya. Am J Trop Med Hyg 77: pp. 23-28
  3. Okiro, EA, Al-Taiar, A, Reyburn, H, Idro, R, Berkley, JA, Snow, RW (2009) Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. Malar J 8: pp. 4 CrossRef
  4. Korenromp, EL, Armstrong-Schellenberg, JRM, Williams, BG, Nahlen, BL, Snow, RW (2004) Impact of malaria control on childhood anaemia in Africa 鈥?a quantitative review. Trop Med Int Health 9: pp. 1050-1065 CrossRef
  5. Trampuz, A, Jereb, M, Muzlovic, I, Prabhu, RM (2003) Clinical review: severe malaria. Crit Care 7: pp. 315-323 CrossRef
  6. English, M, Ahmed, M, Ngando, C, Berkley, J, Ross, A (2002) Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet 359: pp. 494-495 CrossRef
  7. Delaney, M, Somuah, D (2010) A malaria control program's effect on paediatric transfusion. Vox Sang 99: pp. 314-318 CrossRef
  8. Meremikwu, M, Smith, HJ (2000) Blood transfusion for treating malarial anaemia. Cochrane Database Syst Rev 2: pp. CD001475
  9. Mosha, D, Poulsen, A, Reyburn, H, Kituma, E, Mtei, F, Bygbjerg, IC (2009) Quality of paediatric blood transfusions in two district hospitals in Tanzania: a cross-sectional hospital based study. BMC Pediatr 9: pp. 51 CrossRef
  10. Lackritz, EM, Campbell, CC, Ruebush, TK, Hightower, AW, Wakube, W, Steketee, RW, Were, JB (1992) Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 340: pp. 524-528 CrossRef
  11. Ala, F, Allain, JP, Bates, I, Boukef, K, Boulton, F, Brandful, J, Dax, EM, El Ekiaby, M, Farrugia, A, Gorlin, J, Hassall, O, Lee, H, Loua, A, Maitland, K, Mbanya, D, Mukhtar, Z, Murphy, W, Opare-Sem, O, Owusu-Ofori, S, Reesink, H, Roberts, D, Torres, O, Totoe, G, Ullum, H, Wendel, S (2012) External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection. PLoS Med 9: pp. e1001309 CrossRef
  12. Bojang, KA, Palmer, A, Boele Van Hensbroek, M, Banya, WA, Greenwood, BM (1997) Management of severe malarial anaemia in Gambian children. Trans R Soc Trop Med Hyg 91: pp. 557-561 CrossRef
  13. Akech, SO, Hassall, O, Pamba, A, Idro, R, Williams, TN, Newton, CR, Maitland, K (2008) Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya. Malar J 7: pp. 256 CrossRef
  Blood Safety and Availability- Fact sheet N.279. World Health Organization, Geneva, Switzerland
  14. Obonyo, CO, Steyerberg, EW, Oloo, AJ, Habbema, JD (1998) Blood transfusions for severe malaria-related anaemia in Africa: a decision analysis. Am J Trop Med Hyg 59: pp. 808-812
  15. Bates, I, Chapotera, GK, McKew, S, van den Broek, N (2008) Maternal mortality in sub-Saharan Africa: the contribution of ineffective blood transfusion services. BJOG 115: pp. 1331-1339 CrossRef
  Universal Access to Safe Blood Transfusion. World Health Organization, Geneva, Switzerland
  16. Osaro, E, Charles, AT (2011) The challenges of meeting the blood transfusion requirements in Sub-Saharan Africa: the need for the development of alternatives to allogenic blood. J Blood Med 2: pp. 7-21 CrossRef
  17. Bhattarai, A, Ali, AS, Kachur, SP, Martensson, A, Abbas, AK, Khatib, R, Al-mafazy, A-W, Ramsan, M, Rotllant, G, Gerstenmaier, JF, Molteni, F, Abdulla, S, Montgomery, SM, Kaneko, A, Bj枚rkman, A (2007) Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med 4: pp. e309 CrossRef
  18. Mulenga, M, Malunga, F, Bennett, S, Thuma, PE, Shulman, C, Fielding, K, Alloueche, A, Greenwood, BM (2006) A randomised, double-blind, placebo-controlled trial of atovaquone鈥損roguanil vs. sulphadoxine鈥損yrimethamine in the treatment of malarial anaemia in Zambian children. Trop Med Int Health 11: pp. 1643-1652 CrossRef
  19. Cairns, M, Roca-Feltrer, A, Garske, T, Wilson, AL, Diallo, D, Milligan, PJ, Ghani, AC, Greenwood, BM (2012) Estimating the potential public health impact of seasonal malaria chemoprevention in African children. Nat Commun 3: pp. 881 CrossRef
  20. Kent, RJ, Thuma, PE, Mharakurwa, S, Norris, DE (2007) Seasonality, blood feeding behavior, and transmission of Plasmodium falciparum by Anopheles arabiensis after an extended drought in southern Zambia. Am J Trop Med Hyg 76: pp. 267-274
  World Malaria Report 2011. World Health Organization, Geneva
  21. Larkin, G, Thuma, P (1991) Congenital malaria in a hyperendemic area. Am J Trop Med Hyg 45: pp. 587-592
  22. Fornadel, CM, Norris, LC, Glass, GE, Norris, DE (2010) Analysis of anopheles arabiensis blood feeding behavior in southern Zambia during the two year after introduction of insecticide-treated bed nets. Am J Trop Med Hyg 83: pp. 848-853 CrossRef
  23. Kelly-Hope, L, McKenzie, F (2009) The multiplicity of malaria transmission: a review of entomological inoculation rate measurements and methods across sub-Saharan Africa. Malar J 8: pp. 19 CrossRef
  24. Sipilanyambe, N, Simon, JL, Chanda, P, Olumese, P, Snow, RW, Hamer, DH (2008) From chloroquine to artemether-lumefantrine: the process of drug policy change in Zambia. Malar J 7: pp. 25 CrossRef
  25. Hamer, DH, Ndhlovu, M, Zurovac, D, Fox, M, Yeboah-Antwi, K, Chanda, P, Sipilinyambe, N, Simon, JL, Snow, RW (2007) Improved diagnostic testing and malaria treatment practices in Zambia. JAMA 297: pp. 2227-2231 CrossRef
  Zambia National Malaria Indicator Survey 2006. Ministry of Health and Central Statistical Office, Lusaka, Zambia
  Zambia National Malaria Indicator Survey 2008. Ministry of Health and Central Statistical Office, Lusaka, Zambia
  World Malaria Report 2010. World Health Organization, Geneva
  26. Chanda, E, Coleman, M, Kleinschmidt, I, Hemingway, J, Hamainza, B, Masaninga, F, Chanda-Kapata, P, Baboo, KS, D眉rrheim, DN, Coleman, M (2012) Impact assessment of malaria vector control using routine surveillance data in Zambia: Implications for monitoring and evaluation. Malar J 11: pp. 437 CrossRef
  
• 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
• 出版者：BioMed Central
• ISSN：1475-2875

文摘

Background Blood transfusions can reduce mortality among children with severe malarial anaemia, but there is limited evidence quantifying the relationship between paediatric malaria and blood transfusions. This study explores the extent to which the use of paediatric blood transfusions is affected by the number of paediatric malaria visits and admissions. It assesses whether the scale-up of malaria control interventions in a facility catchment area explains the use of paediatric blood transfusions. Methods The study was conducted at a referral hospital for 13 rural health centres in rural Zambia. Data were used from facility and patient records covering all paediatric malaria admissions from 2000 to 2008. An interrupted time series analysis using an autoregression-moving-average model was conducted to assess the relationship between paediatric malaria outpatient visits and admissions and the use of paediatric blood transfusions. Further investigation explored whether the use of paediatric blood transfusions over time was consistent with the roll out of malaria control interventions in the hospital catchment area. Results For each additional paediatric malaria outpatient visit, there were 0.07 additional paediatric blood transfusions (95% CI 0.01-0.13; p p p p Conclusions Paediatric admissions for severe malarial anaemia largely explain total use of paediatric blood transfusions. The reduction in paediatric blood transfusions is consistent with the timing of the malaria control interventions. Malaria control seems to influence the use of paediatric blood transfusions by reducing the number of paediatric admissions for severe malarial anaemia. Reduced use of blood transfusions could benefit other areas of the health system through greater blood availability, particularly where supply is limited.