One-year outcome of postoperative swallowing impairment in pediatric patients with posterior fossa brain tumor

详细信息    查看全文

• 作者：Woo Hyung Lee ; Byung-Mo Oh ; Han Gil Seo ; Seung-Ki Kim…
• 关键词：Brainstem ; Child ; Deglutition disorders ; Neurosurgery ; Posterior fossa brain tumor
• 刊名：Journal of Neuro-Oncology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：127
• 期：1
• 页码：73-81
• 全文大小：877 KB
• 参考文献：1.Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63:11–30CrossRef PubMed
  2.Pollack IF (1994) Brain tumors in children. N Engl J Med 331:1500–1507CrossRef PubMed
  3.Kaatsch P (2010) Epidemiology of childhood cancer. Cancer Treat Rev 36:277–285CrossRef PubMed
  4.Fuemmeler BF, Elkin TD, Mullins LL (2002) Survivors of childhood brain tumors: behavioral, emotional, and social adjustment. Clin Psychol Rev 22:547–585CrossRef PubMed
  5.Piscione PJ, Bouffet E, Mabbott DJ, Shams I, Kulkarni AV (2014) Physical functioning in pediatric survivors of childhood posterior fossa brain tumors. Neuro Oncol 16:147–155PubMedCentral CrossRef PubMed
  6.Rashidi M, DaSilva VR, Minagar A, Rutka JT (2003) Nonmalignant pediatric brain tumors. Curr Neurol Neurosci Rep 3:200–205CrossRef PubMed
  7.Brinkman TM, Reddick WE, Luxton J, Glass JO, Sabin ND, Srivastava DK, Robison LL, Hudson MM, Krull KR (2012) Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. Neuro Oncol 14 Suppl 4:iv25–36
  8.Ullrich NJ (2009) Neurologic sequelae of brain tumors in children. J Child Neurol 24:1446–1454CrossRef PubMed
  9.Macedoni-lukˇ M (2003) Long-term sequelae in children treated for brain tumors: Impairments, disability, and handicap. Pediatr Hematol Oncol 20(2):89–101CrossRef
  10.Lannering B, Marky I, Lundberg A, Olsson E (1990) Long-term sequelae after pediatric brain tumors: Their effect on disability and quality of life. Med Pediatr Oncol 18:304–310CrossRef PubMed
  11.Mei C, Morgan AT (2011) Incidence of mutism, dysarthria and dysphagia associated with childhood posterior fossa tumour. Child’s Nerv Syst 27:1129–1136CrossRef
  12.Morgan AT, Sell D, Ryan M, Raynsford E, Hayward R (2008) Pre and post-surgical dysphagia outcome associated with posterior fossa tumour in children. J Neurooncol 87:347–354CrossRef PubMed
  13.Newman LA, Boop FA, Sanford RA, Thompson JW, Temple CK, Duntsch CD (2006) Postoperative swallowing function after posterior fossa tumor resection in pediatric patients. Childs Nerv Syst 22:1296–1300CrossRef PubMed
  14.Pollack IF, Polinko P, Albright AL, Towbin R, Fitz C (1995) Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37:885–893CrossRef PubMed
  15.Ram Z, Grossman R (2014) Dysphagia as a complication of posterior fossa surgery in adults. World Neurosurg 82:625–626CrossRef PubMed
  16.Farmer J-P, Montes JL, Freeman CR, Meagher-Villemure K, Bond MC, O’Gorman AM (2001) Brainstem gliomas. Pediatr Neurosurg 34:206–214CrossRef PubMed
  17.Lee JY, Kim I-K, Phi JH, Wang K-C, Cho B-K, Park S-H, Ahn HS, Kim IH, Kim S-K (2012) Atypical teratoid/rhabdoid tumors: the need for more active therapeutic measures in younger patients. J Neurooncol 107:413–419CrossRef PubMed
  18.National Dysphagia Diet Task Force (2002) National dysphagia diet: standardization for optimal care. American Dietetic Association, Chicago
  19.Brien WTO (2013) Imaging of primary posterior fossa brain tumors in children. J Am Osteopath Coll Radiol 2:2–12
  20.Lang IM (2009) Brain stem control of the phases of swallowing. Dysphagia 24:333–348CrossRef PubMed
  21.Teo C, Nakaji P, Symons P, Tobias V, Cohn R, Smee R (2003) Ependymoma. Child’s Nerv Syst 19:270–285CrossRef
  22.Grondin RT, Scott RM, Smith ER (2009) Pediatric brain tumors. Adv Pediatr 56:249–269CrossRef PubMed
  23.Kim Y-J, Kim J-Y, Lim DH et al (2013) Retrospective analysis of treatment outcome of pediatric ependymomas in Korea: analysis of Korean multi-institutional data. J Neurooncol 113:39–48CrossRef PubMed
  24.Han TR, Paik N-J, Park J-W, Kwon BS (2008) The prediction of persistent dysphagia beyond 6 months after stroke. Dysphagia 23:59–64CrossRef PubMed
  25.Mann G, Hankey GJ, Cameron D (1999) Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke 30:744–748CrossRef PubMed
  26.Kim W, Kim H, Hae H, Sung C, Oh J, Jae H, Myeong Y, Ku S, Mo B, Oh B (2012) Abnormal videofluoroscopy swallow study finding in inflammatory myopathy patient with dysphagia as predictor of prognosis. Arthritis Rheum 64 Suppl 10:215. doi:10.​1002/​art.​37950
  27.Logemann JA (2006) Medical and rehabilitative therapy of oral, pharyngeal motor disorders. GI Motil online. doi:10.​1038/​gimo50
  28.Massey Benson T RS (2006) Physiology of oral cavity, pharynx and upper esophageal sphincter. GI Motil online. doi:10.​1038/​gimo2
  29.Arvedson JC (2006) Swallowing and feeding in infants and young children. GI Motil online. doi:10.​1038/​gimo17
  
• 作者单位：Woo Hyung Lee (1) (5)
  Byung-Mo Oh (1) (2)
  Han Gil Seo (1)
  Seung-Ki Kim (3)
  Ji Hoon Phi (3)
  Sangjoon Chong (3)
  Tai Ryoon Han (4)
  
  1. Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
  5. Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea
  2. Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  3. Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
  4. Department of Rehabilitation Medicine, Gangwon-Do Rehabilitation Hospital, Chuncheon, Republic of Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Impaired swallowing in children who underwent posterior fossa brain tumor (PFBT) resection disrupts development and quality of life, yet its downstream consequences remain unclear. This study explored the risk factors and functional prognosis of postoperative swallowing impairment in pediatric patients (<19 years old) with PFBT. Among 183 patients with PFBT who underwent surgical resection, 39 patients with postoperative swallowing difficulty were analyzed using the videofluoroscopic swallowing study (VFSS). The association between clinical features, swallowing characteristics, and swallowing impairment was explored during the early postoperative phase and 1-year following surgical resection. Duration of tube feeding was investigated using Kaplan–Meier analysis. Twenty-seven (14.8 %) patients needed tube feeding in the early postoperative phase and 11 (6.01 %) at 1-year after surgical resection. Mean duration of tube feeding was 240.2 days and differed by tumor pathologies (P = 0.001), delayed triggering of pharyngeal swallow (DTP) (P = 0.002) and pharyngeal wall coating (P = 0.033). Tumor pathology was associated significantly with the referral for swallowing evaluation (P < 0.001) and 1-year tube feeding (P = 0.019). Tube feeding at 1-year was significantly associated with the tumor’s brainstem involvement (P = 0.039), and swallowing abnormalities at early phase including DTP (P = 0.030) and pharyngeal wall coating (P = 0.004). Our results suggest that tumor pathology, brainstem involvement, and specific swallowing abnormalities at early phase are important risk factors for sustained 1-year swallowing impairment following surgical resection. These results can be applied to determine the plan of evaluation, nutrition, and intervention in clinical practice.